[图书][B] RNA, the epicenter of genetic information

J Mattick, P Amaral - 2023 - library.oapen.org
The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

Molecular functions of Mrhl lncRNA in mouse spermatogenesis

B Kayyar, S Kataruka, VS Akhade, MRS Rao - Reproduction, 2023 - rep.bioscientifica.com
In brief Mrhl lncRNA regulates the Wnt signaling pathway in mouse spermatogonial cells,
resulting in the commitment of B-type spermatogonia to meiotic entry through Mrhl lncRNA …

m(6)A Modification of lncRNA NEAT1 Regulates Chronic Myelocytic Leukemia Progression via miR-766-5p/CDKN1A Axis

FY Yao, C Zhao, FM Zhong, TY Qin, F Wen… - Frontiers in …, 2021 - frontiersin.org
Background Chronic myeloid leukemia (CML) is an acquired hematopoietic stem malignant
disease originating from the myeloid system. Long non-coding RNAs (lncRNAs) have been …

[HTML][HTML] Downregulation of enhancer RNA EMX2OS is associated with poor prognosis in kidney renal clear cell carcinoma

H Jiang, H Chen, P Wan, S Song, N Chen - Aging (Albany NY), 2020 - ncbi.nlm.nih.gov
Enhancer RNAs are a subclass of long non-coding RNAs transcribed from enhancer regions
that play an important role in the transcriptional regulation of genes. However, their role in …

Enhancers are genes that express organizational RNAs

JS Mattick - Frontiers in RNA Research, 2023 - frontiersin.org
A longstanding enigma in molecular biology is the lack of scaling of protein-coding genes
with developmental complexity, referred to as the g-value paradox. On the other hand, a …

SCAR-6 elncRNA locus epigenetically regulates PROZ and modulates coagulation and vascular function

G Ranjan, P Sehgal, V Scaria, S Sivasubbu - EMBO reports, 2024 - embopress.org
In this study, we characterize a novel lncRNA-producing gene locus that we name Syntenic
Cardiovascular Conserved Region-Associated lncRNA-6 (scar-6) and functionally validate …

Identification of PAX6 and NFAT4 as the transcriptional regulators of the long noncoding RNA Mrhl in neuronal progenitors

D Pal, S Dutta, DP Iyer, D Shriram… - … and Cellular Biology, 2022 - Taylor & Francis
The long noncoding RNA (lncRNA) Mrhl has been shown to be involved in coordinating
meiotic commitment of mouse spermatogonial progenitors and differentiation events in …

Current and emerging molecular and epigenetic disease entities in acute myeloid leukemia and a critical assessment of their therapeutic modalities

X Zhao, H Liu, LN Wang, L Yang, X Liu - Seminars in Cancer Biology, 2022 - Elsevier
Acute myeloid leukemia (AML) is the most frequently diagnosed acute leukemia, and its
incidence increases with age. Although the etiology of AML remains unknown, exposure to …

LncRNA Hmrhl regulates expression of cancer related genes in chronic myelogenous leukemia through chromatin association

SR Choudhury, S Dutta, U Bhaduri, MRS Rao - NAR cancer, 2021 - academic.oup.com
Long non-coding RNA has emerged as a key regulator of myriad gene functions. One such
lncRNA mrhl, reported by our group, was found to have important role in spermatogenesis …

[HTML][HTML] LncRNA Mrhl orchestrates differentiation programs in mouse embryonic stem cells through chromatin mediated regulation

D Pal, CV Neha, U Bhaduri, Z Zenia, S Dutta… - Stem Cell Research, 2021 - Elsevier
Long non-coding RNAs (lncRNAs) have been well-established to act as regulators and
mediators of development and cell fate specification programs. LncRNA Mrhl (meiotic …