The spliced form of X-box binding protein 1 (XBP1s) is an active transcription factor that
plays a vital role in the unfolded protein response (UPR). Under endoplasmic reticulum (ER) …

Se is a micronutrient essential for human health. Sub-optimal Se status is common,
occurring in a significant proportion of the population across the world including parts of …

The unfolded protein response (UPR) is activated upon the accumulation of misfolded
proteins in the endoplasmic reticulum (ER) that are sensed by the binding immunoglobulin …

Hereditary deficiency of the protein α-1 antitrypsin (AAT) causes a chronic lung disease in
humans that is characterized by excessive mobilization of neutrophils into the lung …

The unique chemistry of oxygen has been both a resource and threat for life on Earth for at
least the last 2.4 billion years. Reduction of oxygen to water allows extraction of more …

Accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) lumen
triggers an unfolded protein response (UPR) for stress adaptation, the failure of which …

With the increasing of global mean surface air temperature, heat stress (HS) induced by
extreme high temperature has become a key factor restricting the poultry industry. Liver is …

Reactive oxygen and nitrogen species can be generated endogenously (by mitochondria,
peroxisomes, and phagocytic cells) and exogenously (by pollutions, UV exposure …

Chronic metabolic stress leads to cellular dysfunction, characterized by excessive reactive
oxygen species, endoplasmic reticulum (ER) stress and inflammation, which has been …

Background The impact of selenium status on the long-term health of people with type 2
diabetes (T2D) remains unclear. Objectives To prospectively examine the association of …