Identifying protein complexes and functional modules—from static PPI networks to dynamic PPI networks

B Chen, W Fan, J Liu, FX Wu - Briefings in bioinformatics, 2014 - academic.oup.com
Cellular processes are typically carried out by protein complexes and functional modules.
Identifying them plays an important role for our attempt to reveal principles of cellular …

Recent advances in clustering methods for protein interaction networks

J Wang, M Li, Y Deng, Y Pan - BMC genomics, 2010 - Springer
The increasing availability of large-scale protein-protein interaction data has made it
possible to understand the basic components and organization of cell machinery from the …

Automated network analysis identifies core pathways in glioblastoma

E Cerami, E Demir, N Schultz, BS Taylor, C Sander - PloS one, 2010 - journals.plos.org
Background Glioblastoma multiforme (GBM) is the most common and aggressive type of
brain tumor in humans and the first cancer with comprehensive genomic profiles mapped by …

Construction and application of dynamic protein interaction network based on time course gene expression data

J Wang, X Peng, M Li, Y Pan - Proteomics, 2013 - Wiley Online Library
In recent years, researchers have tried to inject dynamic information into static protein
interaction networks (PIN s). The paper first proposes a three‐sigma method to identify …

Towards the identification of protein complexes and functional modules by integrating PPI network and gene expression data

M Li, X Wu, J Wang, Y Pan - BMC bioinformatics, 2012 - Springer
Background Identification of protein complexes and functional modules from protein-protein
interaction (PPI) networks is crucial to understanding the principles of cellular organization …

Clustering and summarizing protein-protein interaction networks: A survey

SS Bhowmick, BS Seah - IEEE Transactions on Knowledge …, 2015 - ieeexplore.ieee.org
The increasing availability and significance of large-scale protein-protein interaction (ppi)
data has resulted in a flurry of research activity to comprehend the organization, processes …

Dynamic protein interaction network construction and applications

J Wang, X Peng, W Peng, FX Wu - Proteomics, 2014 - Wiley Online Library
With more dynamic information available, researchers' attention has recently shifted from
static properties to dynamic properties of protein–protein interaction networks. To …

In search of the biological significance of modular structures in protein networks

Z Wang, J Zhang - PLoS computational biology, 2007 - journals.plos.org
Many complex networks such as computer and social networks exhibit modular structures,
where links between nodes are much denser within modules than between modules. It is …

Community detection in protein-protein interaction networks and applications

I Manipur, M Giordano, M Piccirillo… - IEEE/ACM …, 2021 - ieeexplore.ieee.org
The ability to identify and characterize not only the protein-protein interactions but also their
internal modular organization through network analysis is fundamental for understanding …

SubMAP: aligning metabolic pathways with subnetwork mappings

F Ay, M Kellis, T Kahveci - Journal of computational biology, 2011 - liebertpub.com
We consider the problem of aligning two metabolic pathways. Unlike traditional approaches,
we do not restrict the alignment to one-to-one mappings between the molecules (nodes) of …