Reactive oxygen species signalling in plant stress responses

R Mittler, SI Zandalinas, Y Fichman… - … reviews Molecular cell …, 2022 - nature.com
Reactive oxygen species (ROS) are key signalling molecules that enable cells to rapidly
respond to different stimuli. In plants, ROS play a crucial role in abiotic and biotic stress …

[HTML][HTML] Oxidative stress in cancer

JD Hayes, AT Dinkova-Kostova, KD Tew - Cancer cell, 2020 - cell.com
Contingent upon concentration, reactive oxygen species (ROS) influence cancer evolution
in apparently contradictory ways, either initiating/stimulating tumorigenesis and supporting …

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

H Sies, DP Jones - Nature reviews Molecular cell biology, 2020 - nature.com
Abstract 'Reactive oxygen species'(ROS) is an umbrella term for an array of derivatives of
molecular oxygen that occur as a normal attribute of aerobic life. Elevated formation of the …

Detection, identification, and quantification of oxidative protein modifications

CL Hawkins, MJ Davies - Journal of Biological Chemistry, 2019 - ASBMB
Exposure of biological molecules to oxidants is inevitable and therefore commonplace.
Oxidative stress in cells arises from both external agents and endogenous processes that …

Selective persulfide detection reveals evolutionarily conserved antiaging effects of S-sulfhydration

J Zivanovic, E Kouroussis, JB Kohl, B Adhikari… - Cell metabolism, 2019 - cell.com
Life on Earth emerged in a hydrogen sulfide (H 2 S)-rich environment eons ago and with it
protein persulfidation mediated by H 2 S evolved as a signaling mechanism. Protein …

2-Oxoglutarate-dependent dioxygenases in cancer

JA Losman, P Koivunen, WG Kaelin Jr - Nature Reviews Cancer, 2020 - nature.com
Oxoglutarate-dependent dioxygenases (2OGDDs) are a superfamily of enzymes that play
diverse roles in many biological processes, including regulation of hypoxia-inducible factor …

Click chemistry in proteomic investigations

CG Parker, MR Pratt - Cell, 2020 - cell.com
Despite advances in genetic and proteomic techniques, a complete portrait of the proteome
and its complement of dynamic interactions and modifications remains a lofty, and as of yet …

S-glycosylation-based cysteine profiling reveals regulation of glycolysis by itaconate

W Qin, KE Qin, Y Zhang, W Jia, Y Chen… - Nature chemical …, 2019 - nature.com
Itaconate has been recently recognized as an anti-inflammatory metabolite involved in the
pathogen–macrophage interface. Due to its weak electrophilicity, itaconate could modify …

Oxidative stress in age-related neurodegenerative diseases: An overview of recent tools and findings

D Korovesis, T Rubio-Tomás, N Tavernarakis - Antioxidants, 2023 - mdpi.com
Reactive oxygen species (ROS) have been described to induce a broad range of redox-
dependent signaling reactions in physiological conditions. Nevertheless, an excessive …

Hsp70 in redox homeostasis

H Zhang, W Gong, S Wu, S Perrett - Cells, 2022 - mdpi.com
Cellular redox homeostasis is precisely balanced by generation and elimination of reactive
oxygen species (ROS). ROS are not only capable of causing oxidation of proteins, lipids and …