Serum testosterone (TS) levels decrease with aging in both humans and rodents. Using the
rat as a model system, it was found that age-related reductions in serum TS were not due to …

Steroid hormones are synthesized in the adrenal gland, gonads, placenta and brain and are
critical for normal reproductive function and bodily homeostasis. The steroidogenic acute …

All animal subcellular membranes require cholesterol, which influences membrane fluidity
and permeability, fission and fusion processes, and membrane protein function. The …

The gonadotropin FSH plays a key role in the control of Sertoli cell function. The FSH
molecular mechanism of action is best recognized for its stimulation of the adenylyl …

The adrenal cortex is critical for physiological function as the central site of glucocorticoid
and mineralocorticoid synthesis. It possesses a great degree of specialized …

The family of StAR related lipid transfer proteins (START) is so-named based on the
distinctive capacity for these proteins to transport lipids between membranes. The START …

The zona fasciculata (zF) in the adrenal cortex contributes to multiple physiological actions
through glucocorticoid synthesis. The size, proliferation, and glucocorticoid synthesis …

Nicotinamide nucleotide transhydrogenase, NNT, is a ubiquitous protein of the inner
mitochondrial membrane with a key role in mitochondrial redox balance. NNT produces high …

Steroidogenesis takes place mainly in adrenal and gonadal cells that produce a variety of
structurally similar hormones regulating numerous body functions. The rate-limiting stage of …

STARD1 moves cholesterol (CHOL) from the outer mitochondrial membrane (OMM) to the
inner membrane (IMM) in steroidogenic cells. This activity is integrated into CHOL trafficking …