Skeletal muscle is a malleable tissue capable of altering the type and amount of protein in
response to disruptions to cellular homeostasis. The process of exerciseinduced adaptation …

▪ Abstract The protein kinase Akt/PKB is activated via a multistep process by a variety of
signals. In the early steps of this process, PI-3 kinase-generated D3-phosphorylated …

The broad nature of insulin resistant glucose metabolism in skeletal muscle of patients with
type 2 diabetes suggests a defect in the proximal part of the insulin signaling network. We …

Total GLUT4 content in skeletal muscle from individuals with type 2 diabetes is normal;
however, recent studies have demonstrated that translocation of GLUT4 to the plasma …

Contracting skeletal muscles acutely increases glucose transport in both healthy individuals
and in people with Type 2 diabetes, and regular physical exercise is a cornerstone in the …

This review focuses on two paralogue Rab GTPase activating proteins known as TBC1D1
Tre-2/BUB2/cdc 1 domain family (TBC1D) 1 and TBC1D4 (also called Akt Substrate of 160 …

Background Preoperative oral carbohydrate (OCH) reduces postoperative insulin resistance
(PIR). This randomized trial investigated whether this effect is related to insulin-induced …

The molecular signaling mechanisms by which muscle contractions lead to changes in
glucose metabolism and gene expression remain largely undefined. We assessed whether …

Studies in rodents have established that GLUT-4 translocation is the major mechanism by
which insulin and exercise increase glucose uptake in skeletal muscle. In contrast, much …

Cell surface GLUT4 levels in skeletal muscle from nine type 2 diabetic subjects and nine
healthy control subjects have been assessed by a new technique that involves the use of a …