Genotoxicity data are mainly interpreted in a qualitative way, which typically results in a
binary classification of chemical entities. For more than a decade, there has been a …

Although occupational exposure to antimony and its compounds can produce pulmonary
toxicity, human carcinogenic impacts have not been observed. Inhalation studies with …

SMA is an inherited disease that leads to loss of motor function and ambulation and a
reduced life expectancy. We have been working to develop orally administrated …

Among naturally occurring plant constituents, the 1, 2-unsaturated pyrrolizidine alkaloids (in
the following termed 'PAs') play a distinct role because of the large number of congeners …

Exposure to chemical agents is an inevitable consequence of modern society; some of these
agents are hazardous to human health. The effects of chemical carcinogens are of great …

The biologic effects of inorganic arsenic predominantly involve reaction of the trivalent forms
with sulfhydryl groups in critical proteins in target cells, potentially leading to various …

A genotoxic carcinogen, N‐nitrosodimethylamine (NDMA), was detected as a synthesis
impurity in some valsartan drugs in 2018, and other N‐nitrosamines, such as N …

Abstract Plant-based 1, 2-unsaturated Pyrrolizidine Alkaloids (PAs) can be found as
contaminants in foods like teas, herbs and honey. PAs are responsible for liver genotoxicity …

This report summarizes the discussion, conclusions, and points of consensus of the IWGT
Working Group on Quantitative Approaches to Genetic Toxicology Risk Assessment (QWG) …

The screen‐and‐bin approach for interpretation of genotoxicity data is predicated on three
false assumptions: that genotoxicants are rare, that genotoxicity dose–response functions do …