[HTML][HTML] A Focused Review on Cognitive Improvement by the Genus Salvia L. (Sage)—From Ethnopharmacology to Clinical Evidence
Ethnopharmacology has been an important starting point in medical and pharmaceutical
sciences for discovering drug candidates from natural sources. In this regard, the genus …
sciences for discovering drug candidates from natural sources. In this regard, the genus …
[HTML][HTML] Insight into the emerging and common experimental in-vivo models of Alzheimer's disease
R Dhapola, S Kumari, P Sharma… - Laboratory Animal …, 2023 - Springer
Alzheimer's disease (AD) is a multifactorial, rapidly progressing neurodegenerative disorder.
As the exact cause of the disease is still unclear, the drug development is very challenging …
As the exact cause of the disease is still unclear, the drug development is very challenging …
Mitochondrial respiration in microglia is essential for response to demyelinating injury but not proliferation
Microglia are necessary for central nervous system (CNS) function during development and
play roles in ageing, Alzheimer's disease and the response to demyelinating injury,,,–. The …
play roles in ageing, Alzheimer's disease and the response to demyelinating injury,,,–. The …
[HTML][HTML] Idebenone regulates Aβ and LPS-induced neurogliosis and cognitive function through inhibition of NLRP3 inflammasome/IL-1β axis activation
Idebenone is an analogue of coenzyme Q10, an electron donor in the mitochondrial electron
transport chain, and thus may function as an antioxidant to facilitate mitochondrial function …
transport chain, and thus may function as an antioxidant to facilitate mitochondrial function …
[HTML][HTML] Neuroprotective effect of nose-to-brain delivery of Asiatic acid in solid lipid nanoparticles and its mechanisms against memory dysfunction induced by Amyloid …
R Islamie, SLL Myint, T Rojanaratha, G Ritthidej… - … Medicine and Therapies, 2023 - Springer
Abstract Background Amyloid-β1-42 (Aβ1-42) plays an essential role in the development of
the early stage of Alzheimer's disease (AD). Asiatic acid (AA), an active compound in …
the early stage of Alzheimer's disease (AD). Asiatic acid (AA), an active compound in …
[HTML][HTML] A systematic review and meta-analysis of tau phosphorylation in mouse models of familial Alzheimer's disease
Transgenic models of familial Alzheimer's disease (AD) serve as valuable tools for probing
the molecular mechanisms associated with amyloid-beta (Aβ)-induced pathology. In this …
the molecular mechanisms associated with amyloid-beta (Aβ)-induced pathology. In this …
[HTML][HTML] long-term treatment of Cuban policosanol attenuates abnormal oxidative stress and inflammatory response via amyloid plaques reduction in 5xFAD Mice
JH Kim, DK Lim, YH Suh, KA Chang - Antioxidants, 2021 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder resulting in cognitive
decline or dementia, the number of patients with AD is continuously increasing. Although a …
decline or dementia, the number of patients with AD is continuously increasing. Although a …
Detection of early proteomic alterations in 5xFAD Alzheimer's disease neonatal mouse model via MALDI‐MSI
I Uras, M Karayel‐Basar, B Sahin… - Alzheimer's & …, 2023 - Wiley Online Library
Alzheimer's disease (AD) is a debilitating neurodegenerative disorder, characterized by
memory deficit and dementia. AD is considered a multifactorial disorder where multiple …
memory deficit and dementia. AD is considered a multifactorial disorder where multiple …
[HTML][HTML] Characterization of a mouse model of Alzheimer's disease expressing Aβ4-42 and human mutant tau
The relationship between the two most prominent neuropathological hallmarks of
Alzheimer's Disease (AD), extracellular amyloid-β (Aβ) deposits and intracellular …
Alzheimer's Disease (AD), extracellular amyloid-β (Aβ) deposits and intracellular …
[HTML][HTML] Resilient Hippocampal Gamma Rhythmogenesis and Parvalbumin-Expressing Interneuron Function Before and After Plaque Burden in 5xFAD Alzheimer's …
CA Mackenzie-Gray Scott, KA Pelkey… - Frontiers in synaptic …, 2022 - frontiersin.org
Recent studies have implicated impaired Parvalbumin Fast-Spiking Interneuron (PVIN)
function as a precipitating factor underlying abnormalities in network synchrony, oscillatory …
function as a precipitating factor underlying abnormalities in network synchrony, oscillatory …