Voltage-gated calcium (Ca2+) channels are key transducers of membrane potential
changes into intracellular Ca2+ transients that initiate many physiological events. There are …

Ryanodine receptors (RyRs) are located in the sarcoplasmic/endoplasmic reticulum
membrane and are responsible for the release of Ca2+ from intracellular stores during …

The ryanodine receptors (RyRs) are a family of Ca2+ release channels found on
intracellular Ca2+ storage/release organelles. The RyR channels are ubiquitously …

There are Ca channels in the plasma membrane and also the sarcoplasmic reticulum (SR)
membrane in cardiac myocytes. The relationship between channel structure, associated …

Voltage-activated calcium channels regulate the intracellular calcium concentration and
contribute thereby to calcium signalling in numerous cell types. These channels are widely …

Malignant hyperthermia (MH) is a potentially life‐threatening event in response to anesthetic
triggering agents, with symptoms of sustained uncontrolled skeletal muscle calcium …

Describes the mechanisms involved in Ca [sup2+] release from sarcoplasmic reticulum of
skeletal muscle that regulates contraction. Overview of excitation-contraction coupling in …

Release of Ca2+ ions from intracellular stores can occur via two classes of Ca2+-release
channel (CRC) protein, the inositol 1, 4, 5-trisphosphate receptors (Ins P 3Rs) and the …

There is an overwhelming body of work supporting the idea that excitation–contraction
coupling in skeletal muscle depends on a physical interaction between the skeletal muscle …

The dihydropyridine receptor (DHPR) in the skeletal muscle plasmalemma functions as both
voltage-gated Ca 2+ channel and voltage sensor for excitation-contraction (EC) coupling. As …