Polyethylenimine (PEI) has recently been widely studied for the design of nucleic acid
delivery vehicles. Gene delivery using PEI involves condensation of DNA into compact …

Oppositely charged polymers can undergo the process of complex coacervation, which
refers to a liquid–liquid phase separation driven by electrostatic attraction. These materials …

Molecular dynamics simulations are used to model proteins that diffuse to DNA, bind, and
dissociate; in the absence of any explicit interaction between proteins, or between …

Polyelectrolytes may be classified into two primary categories (strong and weak) depending
on how their charge state responds to the local environment. Both of these find use in many …

Phase separation of aqueous solutions containing polyelectrolytes can lead to formation of
dense, solute-rich liquid droplets referred to as coacervates, surrounded by a dilute …

The success of polyethyleneimine (PEI) as a nonviral-based gene delivery vector has been
attributed to its proton buffering capacity. Despite the great interest in PEI for its use in …

Complex coacervates are liquid–liquid phase separated systems, typically containing
oppositely charged polyelectrolytes. They are widely studied for their functional properties …

Our revisit of the complexation between anionic DNA and cationic polyethylenimine (PEI) in
both water and phosphate buffered saline (PBS) by using a combination of laser light …

The development of safe, efficient and controllable gene-delivery vectors has become a
bottleneck to human gene therapy. Synthetic polymeric vectors, although safer than viral …

Complexes formed by DNA and polyethylenimine (PEI) are of great research interest
because of their application in gene therapy. In this work, we carried out all-atom molecular …