Since its initial demonstration in 2000, far-field super-resolution light microscopy has
undergone tremendous technological developments. In parallel, these developments have …

Super-resolution fluorescence microscopy allows the investigation of cellular structures at
nanoscale resolution using light. Current developments in super-resolution microscopy have …

Advances in super-resolution microscopy have demonstrated single-molecule localization
precisions of a few nanometers. However, translation of such high localization precisions …

Single-molecule localization microscopy (SMLM) generates data in the form of coordinates
of localized fluorophores. Cluster analysis is an attractive route for extracting biologically …

Efficient gene expression requires RNA polymerase II (RNAPII) to find chromatin targets
precisely in space and time. How RNAPII manages this complex diffusive search in three …

The role of the spatial organization of chromosomes in directing transcription remains an
outstanding question in gene regulation. Here, we analyze two recent single-cell imaging …

Single-molecule localization microscopy super-resolution methods rely on stochastic
blinking/binding events, which often occur multiple times from each emitter over the course …

Photoactivated localization microscopy (PALM) produces an array of localization
coordinates by means of photoactivatable fluorescent proteins. However, observations are …

Blinking carbon dots (CDs) have attracted attention as a probe for single molecule
localization microscopy (SMLM), yet quantitative analysis is limited because of inept blinking …

Immunotherapy including immune checkpoint inhibition has reinvigorated the current cancer
treatment field. The development of efficient cancer immunotherapies depends on a …