This review article is an effort to summarize recent developments in researches providing
uracil derivatives with promising biological potential. This article also aims to discuss …

Thienopyrimidine scaffold is a fused heterocyclic ring system that structurally can be
considered as adenine, the purine base that is found in both DNA and RNA-bioisosteres …

Some novel substituted pyrazole and pyrazolo [3, 4-d] pyrimidine derivatives 2, 4, 8, and 9
were synthesized. Also, some acyclic S-nucleosides of pyrazolo [3, 4-d] pyrimidine …

A new series of thieno [2′, 3′: 4, 5] pyrimido [1, 2-b][1, 2, 4] triazines and thieno [2, 3-d][1,
2, 4] triazolo [1, 5-a] pyrimidines was synthesized. The newly synthesized compounds were …

Several derivatives containing dihydronaphtho, naphtho [2, 1-b] thiophene and thieno [2, 3-
d] pyrimidine ring systems were prepared starting from 2-amino-4, 5-dihydronaphtho [2, 1-b] …

5-Amino-1-substituted-1H-pyrazole-4-carbonitrile derivative 1 was used as a precursor for
preparation of some novel substituted pyrazole and pyrazolo [3, 4-d] pyrimidine derivatives 2 …

Epidermal growth factor receptor (EGFR) and its subtype human epidermal growth factor
receptor 2 (HER2) gets activated when its endogenous ligand (s) bind to its ATP binding site …

A group of EGFR inhibitors derived from thieno [2, 3-d] pyrimidine nucleus was designed,
synthesised, and examined as anti-proliferative lead compounds. MCF-7 and A549 cell lines …

Abstract Pyrazolo [3, 4-d] pyrimidine ring system constitute an important class of heterocyclic
compounds which can serve as a promising scaffold exhibiting many pharmacological …

Two series of new tetrahydrobenzo [4, 5] thieno [2, 3-d] pyrimidines namely 2, 3-
disubstituted derivatives 3a–z and 2, 4-disubstituted ones 6a–c were prepared and tested …