Covering: 2016. Previous review: Nat. Prod. Rep., 2017, 34, 235–294 This review covers the
literature published in 2016 for marine natural products (MNPs), with 757 citations (643 for …

Most of us live blissfully unaware of the orchestrated function that our internal organs
conduct. When this peace is interrupted, it is often by routine sensations of hunger and urge …

The review of the 2016–2017 marine pharmacology literature was prepared in a manner
similar as the 10 prior reviews of this series. Preclinical marine pharmacology research …

The κ-opioid receptor (KOR) has recently emerged as an alternative therapeutic target for
the development of pain medications, without deleterious side effects associated with the μ …

This paper is the thirty-ninth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2016 …

Venoms have evolved> 100 times in all major animal groups, and their components, known
as toxins, have been fine-tuned over millions of years into highly effective biochemical …

Drugs targeting the μ-opioid receptor (MOR) remain the most efficacious analgesics for the
treatment of pain, but activation of MOR with current opioid analgesics also produces …

G protein-coupled receptors (GPCRs) represent important drug targets, as they regulate
pivotal physiological processes and they have proved to be readily druggable. Natural …

Background Isotalatizidine is a representative C 19-diterpenoid alkaloid extracted from the
lateral roots of Aconitum carmichaelii, which has been widely used to treat various diseases …

The rising opioid crisis has become a worldwide societal and public health burden, resulting
from the abuse of prescription opioids. Targeting the κ-opioid receptor (KOR) in the …