Vaccination with heptavalent pneumococcal conjugate vaccine (PCV7) has significantly
reduced the burden of pneumococcal disease and has had an important public health …

Background Vaccines may reduce antibiotic use and the development of resistance.
Objectives To provide a comprehensive, up-to-date assessment of the evidence base …

Rationale: Many bacterial pathogens causing respiratory infections in children are common
residents of the respiratory tract. Insight into bacterial colonization patterns and microbiota …

The nasopharynx is the ecological niche for many commensal bacteria and for potential
respiratory or invasive pathogens like Streptococcus pneumoniae, Haemophilus influenzae …

Rationale: Breastfeeding elicits significant protection against respiratory tract infections in
infancy. Modulation of respiratory microbiota might be part of the natural mechanisms of …

Bacterial pneumonia is a major cause of morbidity and mortality in elderly. We hypothesize
that dysbiosis between regular residents of the upper respiratory tract (URT) microbiome …

Background We investigated the effect of the 7-valent pneumococcal conjugate vaccine
(PCV7) programme in England on serotype-specific carriage and invasive disease to help …

The measurement of pneumococcal carriage in the nasopharyngeal reservoir is subject to
potential confounders that include low-density and multiple-strain colonization. To compare …

Background High rates of potentially pathogenic bacteria and respiratory viruses can be
detected in the upper respiratory tract of healthy children. Investigating presence of and …

Introduction Accurate analyses of microbiota composition of low-density communities (103–
104 bacteria/sample) can be challenging. Background DNA from chemicals and …