The β‐site APP cleaving enzymes 1 and 2 (BACE 1 and BACE 2) were initially identified as
transmembrane aspartyl proteases cleaving the amyloid precursor protein (APP). BACE 1 is …

Melanosomes are tissue-specific lysosome-related organelles of pigment cells in which
melanins are synthesized and stored. Analyses of the trafficking and fate of melanosomal …

The Eneolithic Botai culture of the Central Asian steppes provides the earliest
archaeological evidence for horse husbandry,~ 5500 years ago, but the exact nature of early …

The genomic changes underlying both early and late stages of horse domestication remain
largely unknown. We examined the genomes of 14 early domestic horses from the Bronze …

Current genetic data are equivocal as to whether goat domestication occurred multiple times
or was a singular process. We generated genomic data from 83 ancient goats (51 with …

Intense selective pressures applied over short evolutionary time have resulted in
homogeneity within, but substantial variation among, horse breeds. Utilizing this population …

During the last decade, coat colouration in mammals has been investigated in numerous
studies. Most of these studies addressing the genetics of coat colouration were on …

An equine SNP genotyping array was developed and evaluated on a panel of samples
representing 14 domestic horse breeds and 18 evolutionarily related species. More than …

PMEL is a pigment cell‐specific protein responsible for the formation of fibrillar sheets within
the pigment organelle, the melanosome. The fibrillar sheets serve as a template upon which …

Vertebrate pigmentation patterns are amongst the best characterised model systems for
studying the genetic basis of adaptive evolution. The wealth of available data on the genetic …