Spinal cord interneurons play critical roles shaping motor output, but their precise identity
and connectivity remain unclear. Focusing on the V1 interneuron cardinal class we defined …

Amyotrophic lateral sclerosis (ALS) consists of a group of adult-onset fatal and incurable
neurodegenerative disorders characterized by the progressive death of motor neurons …

The differential expression of transcription factors during embryonic development has been
selected as the main feature to define the specific subclasses of spinal interneurons …

Motor activity is organized by neuronal networks composed of motor neurons and a wide
variety of pre-motor interneuron populations located in the brainstem and spinal cord …

Vertebrates exhibit a wide range of motor behaviors, ranging from swimming to complex
limb-based movements. Here we take advantage of frog metamorphosis, which captures a …

The vertebrate neural tube generates a large diversity of molecularly and functionally distinct
neurons and glia from a small progenitor pool. While the role of spatial patterning in …

While considerable progress has been made in understanding the neuronal circuits that
underlie the patterning of locomotor behaviours such as walking, less is known about the …

Locomotion is a complex behavior that allows us to move and interact with the surroundings.
In mammals, descending locomotor commands from the brainstem act directly onto spinal …