The N-methyl-d-aspartate (NMDA) receptor antagonist ketamine has rapid and potent
antidepressant effects in treatment-resistant major depressive disorder and bipolar …

Objective Chronic cancer pain is often refractory and difficult to treat. Ketamine is a
medication with evidence of efficacy in the treatment of chronic pain. Design This article …

Objectives Currently ketamine is not used often as an analgesic in the emergency
department (ED). Nonetheless, it can increase the efficiency of opioids and decrease their …

Guanosine is an extracellular signaling molecule implicated in the modulation of
glutamatergic transmission and neuroprotection. The present study evaluated the …

Background: Of all the postsurgical pain conditions, thoracotomy pain poses a particular
therapeutic challenge in terms of its prevalence, severity, and ensuing postoperative …

Ketamine, in subanesthetic doses, produces systemic analgesia in chronic pain settings, an
action largely attributed to block of N-methyl-D-aspartate receptors in the spinal cord and …

Spider venoms are known to contain proteins and polypeptides that perform various
functions including antimicrobial, neurotoxic, analgesic, cytotoxic, necrotic, and …

Ketamine, an NMDA receptor antagonist, has been approved to have analgesic effects. It is
known that nitric oxide pathway is involved in antinociception but with dual effects. In this …

The modulation of N-methyl-D-aspartate receptor (NMDAR) and l-arginine/nitric oxide (NO)
pathway is a therapeutic strategy for treating depression and neurologic disorders that …

OBJECTIVE: To assess whether oral ketamine is safe at higher dosages for sedating
children and whether it may be an option for the control of chronic pain in children. STUDY …