In principle, proton therapy offers a substantial clinical advantage over conventional photon
therapy. This is because of the unique depth-dose characteristics of protons, which can be …

Radiotherapy with high-energy charged particles has become an attractive therapeutic
option for patients with several tumour types because this approach better spares healthy …

The NCCN Guidelines for Head and Neck (H&N) Cancers provide treatment
recommendations for cancers of the lip, oral cavity, pharynx, larynx, ethmoid and maxillary …

The original rationale for proton therapy was its highly conformal depth‐dose distributions
compared to photons, which allow greater sparing of normal tissues and escalation of tumor …

Radiation therapy (RT) plays a key role in curative-intent treatments for head and neck
cancers. Its use is indicated as a sole therapy in early stage tumors or in combination with …

Charged particle therapy has been largely driven and influenced by nuclear physics. The
increase in energy deposition density along the ion path in the body allows reducing the …

Background Sinonasal neoplasms, whether benign and malignant, pose a significant
challenge to clinicians and represent a model area for multidisciplinary collaboration in …

Perineural invasion (PNI), the neoplastic invasion of nerves, is a common pathologic finding
in head and neck cancer that is associated with poor clinical outcomes. PNI is a histologic …

Radiation therapy plays an integral role in the management of head and neck cancers
(HNCs). While most HNC patients have historically been treated with photon-based …

Radiation is a significant treatment for patients with head and neck cancer. Despite
advances to improve treatment, many tumors acquire radiation resistance resulting in poor …