Tackling the emerging threat of antifungal resistance to human health
Invasive fungal infections pose an important threat to public health and are an under-
recognized component of antimicrobial resistance, an emerging crisis worldwide. Across a …
recognized component of antimicrobial resistance, an emerging crisis worldwide. Across a …
CAR T therapy beyond cancer: the evolution of a living drug
Engineering a patient's own T cells to selectively target and eliminate tumour cells has cured
patients with untreatable haematologic cancers. These results have energized the field to …
patients with untreatable haematologic cancers. These results have energized the field to …
Aspergillus fumigatus and Aspergillosis in 2019
JP Latgé, G Chamilos - Clinical microbiology reviews, 2019 - Am Soc Microbiol
Aspergillus fumigatus is a saprotrophic fungus; its primary habitat is the soil. In its ecological
niche, the fungus has learned how to adapt and proliferate in hostile environments. This …
niche, the fungus has learned how to adapt and proliferate in hostile environments. This …
Threats posed by the fungal kingdom to humans, wildlife, and agriculture
The fungal kingdom includes at least 6 million eukaryotic species and is remarkable with
respect to its profound impact on global health, biodiversity, ecology, agriculture …
respect to its profound impact on global health, biodiversity, ecology, agriculture …
Killing mechanisms of chimeric antigen receptor (CAR) T cells
MR Benmebarek, CH Karches, BL Cadilha… - International journal of …, 2019 - mdpi.com
Effective adoptive T cell therapy (ACT) comprises the killing of cancer cells through the
therapeutic use of transferred T cells. One of the main ACT approaches is chimeric antigen …
therapeutic use of transferred T cells. One of the main ACT approaches is chimeric antigen …
The antifungal pipeline: a reality check
JR Perfect - Nature reviews Drug discovery, 2017 - nature.com
Invasive fungal infections continue to appear in record numbers as the
immunocompromised population of the world increases, owing partially to the increased …
immunocompromised population of the world increases, owing partially to the increased …
Aspergillus fumigatus morphology and dynamic host interactions
FL Van De Veerdonk, MS Gresnigt, L Romani… - Nature Reviews …, 2017 - nature.com
Aspergillus fumigatus is an environmental filamentous fungus that can cause life-threatening
disease in immunocompromised individuals. The interactions between A. fumigatus and the …
disease in immunocompromised individuals. The interactions between A. fumigatus and the …
Worldwide emergence of resistance to antifungal drugs challenges human health and food security
The recent rate of emergence of pathogenic fungi that are resistant to the limited number of
commonly used antifungal agents is unprecedented. The azoles, for example, are used not …
commonly used antifungal agents is unprecedented. The azoles, for example, are used not …
CAR-based therapies: opportunities for immuno-medicine beyond cancer
One of the most exciting new therapies for cancer involves the use of autologous T cells that
are engineered to recognize and destroy cancerous cells. Patients with previously …
are engineered to recognize and destroy cancerous cells. Patients with previously …
[HTML][HTML] Fungal infections: immune defense, immunotherapies and vaccines
Invasive fungal infection is an under recognized and emerging global health threat.
Recently, the World Health Organization (WHO) released the first ever list of health …
Recently, the World Health Organization (WHO) released the first ever list of health …