Bloodstream infection (BSI) is defined by positive blood cultures in a patient with systemic
signs of infection and may be either secondary to a documented source or primary—that is …

Severe or life threatening infections are common among patients in the intensive care unit
(ICU). Most infections in the ICU are bacterial or fungal in origin and require antimicrobial …

The massive consumption of antibiotics in the ICU is responsible for substantial ecological
side effects that promote the dissemination of multidrug-resistant bacteria (MDRB) in this …

Carbapenem resistance in difficult-to-treat P. aeruginosa (DTR-PA) strains is primarily
mediated by loss or reduction of the OprD porin, overexpression of the cephalosporinase …

Critically ill patients admitted to intensive care unit (ICU) with severe infections, or those who
develop nosocomial infections, have poor outcomes with substantial morbidity and mortality …

Objectives To determine the association of adequate empirical combination therapy (AECT)
with 30-day all-cause mortality in patients with septic shock due to Pseudomonas …

Key messages In this study including 391 critically ill patients with nosocomial pneumonia
due to Gram-negative pathogens, combination therapy was not associated with a reduced …

Objectives To compare the clinical and microbiological outcomes of patients treated with
beta-lactam monotherapy or combination therapy for Pseudomonas aeruginosa infections …

Debate continues as to the role of combination antibiotic therapy for the management of
Pseudomonas aeruginosa infections. We studied the extent of bacterial killing by and the …

Background Combining aminoglycosides with β-lactam antibiotics for treating serious
infections has not been associated with reduced mortality in previous meta-analyses …