[HTML][HTML] Control of human toxoplasmosis
Toxoplasmosis is caused by Toxoplasma gondii, an apicomplexan parasite that is able to
infect any nucleated cell in any warm-blooded animal. Toxoplasma gondii infects around 2 …
infect any nucleated cell in any warm-blooded animal. Toxoplasma gondii infects around 2 …
[HTML][HTML] Toxoplasma metabolic flexibility in different growth conditions
Apicomplexan parasites have complex metabolic networks that coordinate acquisition of
metabolites by de novo synthesis and by scavenging from the host. Toxoplasma gondii has …
metabolites by de novo synthesis and by scavenging from the host. Toxoplasma gondii has …
[HTML][HTML] A transcriptional network required for bradyzoite development in Toxoplasma gondii is dispensable for recrudescent disease
SL Sokol-Borrelli, SM Reilly, MJ Holmes… - Nature …, 2023 - nature.com
Identification of regulators of Toxoplasma gondii bradyzoite development and cyst formation
is the most direct way to address the importance of parasite development in long-term …
is the most direct way to address the importance of parasite development in long-term …
[HTML][HTML] Cryo-EM structure of cortical microtubules from human parasite Toxoplasma gondii identifies their microtubule inner proteins
In living cells, microtubules (MTs) play pleiotropic roles, which require very different
mechanical properties. Unlike the dynamic MTs found in the cytoplasm of metazoan cells …
mechanical properties. Unlike the dynamic MTs found in the cytoplasm of metazoan cells …
Conditional knockdown of proteins using auxin-inducible degron (AID) fusions in Toxoplasma gondii
Toxoplasma gondii is a member of the deadly phylum of protozoan parasites called
Apicomplexa. As a model apicomplexan, there is a great wealth of information regarding T …
Apicomplexa. As a model apicomplexan, there is a great wealth of information regarding T …
[HTML][HTML] Calmodulin-like proteins localized to the conoid regulate motility and cell invasion by Toxoplasma gondii
Toxoplasma gondii contains an expanded number of calmodulin (CaM)-like proteins whose
functions are poorly understood. Using a combination of CRISPR/Cas9-mediated gene …
functions are poorly understood. Using a combination of CRISPR/Cas9-mediated gene …
AP2XII-1 is a negative regulator of merogony and presexual commitment in Toxoplasma gondii
F Fan, L Xue, X Yin, N Gupta, B Shen - Mbio, 2023 - Am Soc Microbiol
ABSTRACT A transition from the asexual to sexual development in the widespread
intracellular pathogen Toxoplasma gondii requires stage switching in its feline (definitive) …
intracellular pathogen Toxoplasma gondii requires stage switching in its feline (definitive) …
[HTML][HTML] A conserved ankyrin repeat-containing protein regulates conoid stability, motility and cell invasion in Toxoplasma gondii
Apicomplexan parasites are typified by an apical complex that contains a unique
microtubule-organizing center (MTOC) that organizes the cytoskeleton. In apicomplexan …
microtubule-organizing center (MTOC) that organizes the cytoskeleton. In apicomplexan …
[HTML][HTML] Rapid metabolic reprogramming mediated by the AMP-activated protein kinase during the lytic cycle of Toxoplasma gondii
Y Li, Z Niu, J Yang, X Yang, Y Chen, Y Li… - Nature …, 2023 - nature.com
The ubiquitous pathogen Toxoplasma gondii has a complex lifestyle with different metabolic
activities at different stages that are intimately linked to the parasitic environments. Here we …
activities at different stages that are intimately linked to the parasitic environments. Here we …
[HTML][HTML] High-throughput identification of Toxoplasma gondii effector proteins that target host cell transcription
Intracellular pathogens and other endosymbionts reprogram host cell transcription to
suppress immune responses and recalibrate biosynthetic pathways. This reprogramming is …
suppress immune responses and recalibrate biosynthetic pathways. This reprogramming is …