N-Heterocyclic carbenes (NHCs) belong to the popular family of organocatalysts used in a
wide range of reactions, including that for the synthesis of complex natural products and …

The developments of theoretical studies on NHC‐catalyzed [n+ 2](n= 2, 3, 4) and other
cycloaddition/annulation reactions have been summarized in this review. The detailed …

A general mechanistic map involving multiple intermediates and pathways has been
proposed and systematically studied for NHC-catalyzed transformation reactions of …

Although breakthroughs in the N-heterocyclic carbene (NHC)-catalyzed inert C–C bond
activation strategy have been achieved, understanding the role of the catalyst as well as the …

Activation of inert sp3 β-C–H bonds has attracted widespread attention and been developed
with significant progress in recent years, but understanding the mechanism of this kind of …

An increasing number of examples are now being reported that use chiral N-heterocyclic
carbenes (NHCs) in conjunction with Lewis acids to enhance catalytic potential. Herein, we …

Generally, N-heterocyclic carbene (NHC) complexed with carbonyl compounds would
transform into several important active intermediates, ie, enolates, Breslow intermediates, or …

The use of more than one catalyst in one-pot reaction conditions has become a rapidly
evolving protocol in the development of asymmetric catalysis. The lack of molecular insights …

The N-heterocyclic carbene (NHC)-catalyzed oxidative C–H deprotonations have attracted
increasing attention; however, the general mechanism regarding this kind of oxidative …

The N-heterocyclic carbene (NHC)-catalyzed γ-C–H deprotonation/functionalization of α, β-
unsaturated esters with hydrazones leading to the δ-lactams has been theoretically …