Forgetting as a form of adaptive engram cell plasticity

TJ Ryan, PW Frankland - Nature Reviews Neuroscience, 2022 - nature.com
One leading hypothesis suggests that memories are stored in ensembles of neurons (or
'engram cells') and that successful recall involves reactivation of these ensembles. A logical …

Differential impact of stress and environmental enrichment on corticolimbic circuits

MA Smail, BL Smith, N Nawreen, JP Herman - … biochemistry and behavior, 2020 - Elsevier
Stress exposure can produce profound changes in physiology and behavior that can impair
health and well-being. Of note, stress exposure is linked to anxiety disorders and depression …

MEF2 is a key regulator of cognitive potential and confers resilience to neurodegeneration

SJ Barker, RM Raju, NEP Milman, J Wang… - Science translational …, 2021 - science.org
Recent increases in human longevity have been accompanied by a rise in the incidence of
dementia, highlighting the need to preserve cognitive function in an aging population. A …

Behavioral and cognitive factors that affect the success of scent detection dogs

CA Troisi, DS Mills, A Wilkinson, HE Zulch - 2019 - cora.ucc.ie
Scent detection dogs are used in a variety of contexts; however, very few dogs successfully
complete their training, and many others are withdrawn from service prematurely due to both …

Does experience enhance cognitive flexibility? An overview of the evidence provided by the environmental enrichment studies

F Gelfo - Frontiers in behavioral neuroscience, 2019 - frontiersin.org
Neuroplasticity accounts for the ability of the brain to change in both structure and function in
consequence of life experiences. An enhanced stimulation provided by the environment is …

The impact of environmental and social factors on learning abilities: a meta‐analysis

CT Lambert, LM Guillette - Biological Reviews, 2021 - Wiley Online Library
Since the 1950s, researchers have examined how differences in the social and asocial
environment affect learning in rats, mice, and, more recently, a variety of other species …

Environmental enrichment as an experience-dependent modulator of social plasticity and cognition

C Gubert, AJ Hannan - Brain Research, 2019 - Elsevier
Social plasticity is the ability to adaptively change the expression of social behaviour
according to experience, allowing animals to optimize their social relationships in the …

Neuroplastic and cognitive impairment in substance use disorders: a therapeutic potential of cognitive stimulation

P Sampedro-Piquero, DL de Guevara-Miranda… - Neuroscience & …, 2019 - Elsevier
Drug addiction is a chronic and relapsing disorder in which repeated drug exposure
compromises brain neuroplasticity. Brain areas normally involved in learning and goal …

Gene-environment interactions informing therapeutic approaches to cognitive and affective disorders

J Rogers, T Renoir, AJ Hannan - Neuropharmacology, 2019 - Elsevier
Gene-environment interactions drive experience-dependent changes in the brain that alter
cognition, emotion and behaviour. Positive engagement with the environment, through novel …

Therapeutic efficacy of environmental enrichment for substance use disorders

E Galaj, ED Barrera, R Ranaldi - Pharmacology Biochemistry and Behavior, 2020 - Elsevier
Addiction to drug and alcohol is regarded as a major health problem worldwide for which
available treatments show limited effectiveness. The biggest challenge remains to enhance …