Abstract Treatment with statins, inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A
reductase, has proven beneficial preventive effects on cardiovascular events. However …

Statins, inhibitors of the hydroxymethylglutaryl-CoA (HMG-CoA) reductase enzyme, are
molecules of fungal origin. By inhibiting a key step in the sterol biosynthetic pathway statins …

Statins inhibit 3-hydroxy-3-methylglutarylcoenzyme A (HMG-CoA) reductase, the rate-
limiting enzyme in cholesterol biosynthesis, which converts HMG-CoA to mevalonate …

Statin drugs represent a major improvement in the treatment of hypercholesterolemia that
constitutes the main origin of atherosclerosis, leading to coronary heart disease. Besides the …

Background and aims. Gentamicin (GM) is still considered to be an important antibiotic
against life-threatening, gram-negative bacterial infections despite its known nephrotoxic …

Statins, the widely prescribed cholesterol-lowering drugs for the treatment of cardiovascular
disease, cause adverse skeletal muscle side effects ranging from fatigue to fatal …

The use of statins for cardiovascular disease prevention is clearly supported by clinical
evidence. However, in January 2014 the US Food and Drug Administration released an …

Statins are the most prescribed and effective drugs to treat cardiovascular diseases (CVD).
Nevertheless, these drugs can be responsible for skeletal muscle toxicity which leads to …

Myotonia is a symptom of many different acquired and genetic muscular conditions that
impair the relaxation phase of muscular contraction. Myotonia congenita is a specific …

The underlying mechanisms for statin-induced myopathy (SIM) are still equivocal. In this
study, we employ Drosophila melanogaster to dissect possible underlying mechanisms for …