Toxoplasma gondii causes fatal and debilitating brain and eye diseases. Medicines that are
currently used to treat toxoplasmosis commonly have toxic side effects and require …

Great successes have been achieved in developing small-molecule kinase inhibitors as
anticancer therapeutic agents. However, kinase deregulation plays essential roles not only …

T-cell antigen receptor (TCR) signaling is essential for activation, proliferation, and effector
function of T cells. Modulation of both intensity and duration of TCR signaling can regulate …

Apicomplexan parasites have complex life cycles, frequently split between different hosts
and reliant on rapid responses as the parasites react to changing environmental conditions …

The protozoan Toxoplasma gondii, an obligate intracellular parasite, is an etiological agent
of human and animal toxoplasmosis. Treatment regimens for T. gondii-infected patients …

Toxoplasmosis is a parasitic disease caused by the globally distributed protozoan parasite
Toxoplasma gondii, which infects around one-third of the world population. This disease …

New therapies are needed for the treatment of toxoplasmosis, which is a disease caused by
the protozoan parasite Toxoplasma gondii. To this end, we previously developed a potent …

Toxoplasma gondii severely threaten the health of immunocompromised patients and
pregnant women as this parasite can cause several disease, including brain and eye …

Abstract The Pathogen Box is a 400‐strong collection of drug‐like compounds, selected for
their potential against several of the world's most important neglected tropical diseases …

Apicomplexan parasites use Ca 2+-regulated exocytosis to secrete essential virulence
factors from specialized organelles called micronemes. Ca 2+-dependent protein kinases …