New technologies have enabled the investigation of biology and human health at an
unprecedented scale and in multiple dimensions. These dimensions include a myriad of …

Coenzyme A (CoA) is the predominant acyl carrier in mammalian cells and a cofactor that
plays a key role in energy and lipid metabolism. CoA and its thioesters (acyl-CoAs) regulate …

The onset of inflammation is associated with reactive oxygen species and oxidative damage
to macromolecules like 7, 8-dihydro-8-oxoguanine (8-oxoG) in DNA. Because 8-oxoguanine …

Oxidatively generated damage to DNA has been implicated in the pathogenesis of a wide
variety of diseases. Increasingly, interest is also focusing upon the effects of damage to the …

As a prototype of genomics-guided precision medicine, individualized thiopurine dosing
based on pharmacogenetics is a highly effective way to mitigate hematopoietic toxicity of this …

Peroxisomes are membrane-bound organelles involved in many metabolic pathways and
essential for human health. They harbor a large number of enzymes involved in the different …

Nucleotide sugars have essential roles in every living creature. They are the building blocks
of the biosynthesis of carbohydrates and their conjugates. They are involved in processes …

The exploitation of the DNA damage response and DNA repair proficiency of cancer cells is
an important anticancer strategy. The replication and repair of DNA are dependent upon the …

Large-scale chromosomal aberrations are prevalent in human cancer, but their function
remains poorly understood. We established chromosome-engineered hepatocellular …

Polyphosphate (polyP) is a polymer of hundreds of phosphate residues present in all
organisms. In mammals, polyP is involved in crucial physiological processes, including …