Seeking satiety: from signals to solutions
MH Tschöp, JM Friedman - Science Translational Medicine, 2023 - science.org
Remedies for the treatment of obesity date to Hippocrates, when patients with obesity were
directed to “reduce food and avoid drinking to fullness” and begin “running during the night.” …
directed to “reduce food and avoid drinking to fullness” and begin “running during the night.” …
International Union of Basic and Clinical Pharmacology CXIV: Orexin Receptor Function, Nomenclature and Pharmacology
The orexin system consists of the peptide transmitters orexin-A and-B and the G protein-
coupled orexin receptors OX 1 and OX 2. Orexin receptors are capable of coupling to all four …
coupled orexin receptors OX 1 and OX 2. Orexin receptors are capable of coupling to all four …
[HTML][HTML] Dorsal raphe serotonergic neurons suppress feeding through redundant forebrain circuits
Objective Serotonin (5HT) is a well-known anorexigenic molecule, and 5HT neurons of
dorsal raphe nucleus (DRN) have been implicated in suppression of feeding; however, the …
dorsal raphe nucleus (DRN) have been implicated in suppression of feeding; however, the …
Whole brain mapping of orexin receptor mRNA expression visualized by branched in situ hybridization chain reaction
Y Tsuneoka, H Funato - eneuro, 2024 - eneuro.org
Orexins, which are produced within neurons of the lateral hypothalamic area, play a pivotal
role in the regulation of various behaviors, including sleep/wakefulness, reward behavior …
role in the regulation of various behaviors, including sleep/wakefulness, reward behavior …
[HTML][HTML] Discovery and first-time disclosure of CVN766, an exquisitely selective orexin 1 receptor antagonist
A Glen, RW Bürli, D Livermore, W Buffham… - Bioorganic & Medicinal …, 2024 - Elsevier
Modulators of orexin receptors are being developed for neurological illnesses such as sleep
disorders, addictive behaviours and other psychiatric diseases. We herein describe the …
disorders, addictive behaviours and other psychiatric diseases. We herein describe the …
[HTML][HTML] Regulation of stress-induced sleep perturbations by dorsal raphe VGLUT3 neurons in male mice
F Henderson, S Dumas, G Gangarossa, V Bernard… - Cell Reports, 2024 - cell.com
Exposure to stressors has profound effects on sleep that have been linked to serotonin (5-
HT) neurons of the dorsal raphe nucleus (DR). However, the DR also comprises …
HT) neurons of the dorsal raphe nucleus (DR). However, the DR also comprises …
SH2B1 Defends Against Energy Imbalance, Obesity, and Metabolic Disease via a Paraventricular Hypothalamus→ Dorsal Raphe Nucleus Neurocircuit
Y Li, MH Kim, L Jiang, L Baron, LD Faulkner… - Advanced …, 2024 - Wiley Online Library
SH2B1 mutations are associated with obesity, type 2 diabetes, and metabolic dysfunction‐
associated steatotic liver disease (MASLD) in humans. Global deletion of Sh2b1 results in …
associated steatotic liver disease (MASLD) in humans. Global deletion of Sh2b1 results in …
Serotonergic regulation of appetite and sodium appetite
Y Shin, S Kim, JW Sohn - Journal of Neuroendocrinology, 2023 - Wiley Online Library
Serotonin is a neurotransmitter that is synthesized and released from the brainstem raphe
nuclei to affect many brain functions. It is well known that the activity of raphe serotonergic …
nuclei to affect many brain functions. It is well known that the activity of raphe serotonergic …
Orexin receptors in GtoPdb v. 2023.1
G Aston-Jones, P Bonaventure… - IUPHAR/BPS Guide …, 2023 - journals.ed.ac.uk
Orexin receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Orexin
receptors [43]) are activated by the endogenous polypeptides orexin-A and orexin-B (also …
receptors [43]) are activated by the endogenous polypeptides orexin-A and orexin-B (also …
镇痛药物研发的潜在方向
葛婷， 张红星 - 徐州医科大学学报, 2024 - xb.xzhmu.edu.cn
生理状态下, 疼痛是一种保护性反应, 可使机体免受更严重的伤害, 有利于物种生存. 病理状态下,
疼痛作为一种常见的疾病/症状, 严重影响患者的生活质量. 近年来, 疼痛机制研究与镇痛药物 …
疼痛作为一种常见的疾病/症状, 严重影响患者的生活质量. 近年来, 疼痛机制研究与镇痛药物 …