Pathogenesis of human immunodeficiency virus infection

JA Levy - Microbiological reviews, 1993 - Am Soc Microbiol
The lentivirus human immunodeficiency virus (HIV) causes AIDS by interacting with a large
number of different cells in the body and escaping the host immune response against it. HIV …

A TH1→ TH2 switch is a critical step in the etiology of HIV infection

M Clerici, GM Shearer - Immunology today, 1993 - cell.com
This viewpoint proposes that an imbalance in the Tul-type and TH2-type responses
contributes to the immune dysregulation associated wiib HIV infection, and that resistance to …

Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B

J Luban, KL Bossolt, EK Franke, GV Kalpana, SP Goff - Cell, 1993 - cell.com
Retroviral Gag protein is capable of directing the assembly of virion particles independent of
other retroviral elements and plays an important role early in the infection of a ceil. Using the …

Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV-and SIV-infected lymph nodes

TH Finkel, G Tudor-Williams, NK Banda, MF Cotton… - Nature medicine, 1995 - nature.com
Although 13 years have passed since identification of human immunodeficiency virus-1 (HIV-
1) as the cause of AIDS, we do not yet know how HIV kills its primary target, the T cell that …

HIV-exposed uninfected children: a growing population with a vulnerable immune system?

L Afran, M Garcia Knight, E Nduati… - Clinical & …, 2014 - academic.oup.com
Through the successful implementation of policies to prevent mother-to-child-transmission
(PMTCT) of HIV-1 infection, children born to HIV-1-infected mothers are now much less likely …

Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis.

NK Banda, J Bernier, DK Kurahara, R Kurrle… - The Journal of …, 1992 - rupress.org
During human immunodeficiency virus (HIV) infection there is a profound and selective
decrease in the CD4+ population of T lymphocytes. The mechanism of this depletion is not …

Controlling HIV pathogenesis: the role of the noncytotoxic anti-HIV response of CD8+ T cells

JA Levy, CE Mackewicz, E Barker - Immunology today, 1996 - Elsevier
Noncytotoxic CD8+ T cells may play a critical role in preventing progression to disease
following human immunodeficiency virus (HIV) infection. This antiviral response, mediated …

Role of interleukin-10 in T helper cell dysfunction in asymptomatic individuals infected with the human immunodeficiency virus.

M Clerici, TA Wynn, JA Berzofsky… - The Journal of …, 1994 - Am Soc Clin Investig
The loss of T helper cell (TH) function in asymptomatic HIV type 1-infected individuals occurs
before the decline in CD4+ T cells. At least part of the loss in TH function results from …

The human immunodeficiency virus type 1 (HIV-1) CD4 receptor and its central role in promotion of HIV-1 infection

S Bour, R Geleziunas, MA Wainberg - Microbiological reviews, 1995 - Am Soc Microbiol
Interactions between the viral envelope glycoprotein gp120 and the cell surface receptor
CD4 are responsible for the entry of human immunodeficiency virus type 1 (HIV-1) into host …

Changes in interleukin-2 and interleukin-4 production in asymptomatic, human immunodeficiency virus-seropositive individuals.

M Clerici, FT Hakim, DJ Venzon, S Blatt… - The Journal of …, 1993 - Am Soc Clin Investig
Infection with HIV results in an incremental loss of T helper cell (TH) function, which can
occur years before CD4 cell numbers are critically reduced and AIDS is diagnosed. All TH …