Synaptopathies: synaptic dysfunction in neurological disorders–A review from students to students
K Lepeta, MV Lourenco, BC Schweitzer… - Journal of …, 2016 - Wiley Online Library
Synapses are essential components of neurons and allow information to travel coordinately
throughout the nervous system to adjust behavior to environmental stimuli and to control …
throughout the nervous system to adjust behavior to environmental stimuli and to control …
Environment and brain plasticity: towards an endogenous pharmacotherapy
Brain plasticity refers to the remarkable property of cerebral neurons to change their
structure and function in response to experience, a fundamental theoretical theme in the …
structure and function in response to experience, a fundamental theoretical theme in the …
Enriched environments, experience-dependent plasticity and disorders of the nervous system
J Nithianantharajah, AJ Hannan - Nature Reviews Neuroscience, 2006 - nature.com
Behavioural, cellular and molecular studies have revealed significant effects of enriched
environments on rodents and other species, and provided new insights into mechanisms of …
environments on rodents and other species, and provided new insights into mechanisms of …
Cognitive deficits and associated neurological complications in individuals with Down's syndrome
IT Lott, M Dierssen - The Lancet Neurology, 2010 - thelancet.com
Improvements in medical interventions for people with Down's syndrome have led to a
substantial increase in their longevity. Diagnosis and treatment of neurological …
substantial increase in their longevity. Diagnosis and treatment of neurological …
Down syndrome: the brain in trisomic mode
M Dierssen - Nature Reviews Neuroscience, 2012 - nature.com
Down syndrome is the most common form of intellectual disability and results from one of the
most complex genetic perturbations that is compatible with survival, trisomy 21. The study of …
most complex genetic perturbations that is compatible with survival, trisomy 21. The study of …
Genetic and epigenetic networks in intellectual disabilities
H Van Bokhoven - Annual review of genetics, 2011 - annualreviews.org
Mutations in more than 450 different genes have been associated with intellectual disability
(ID) and related cognitive disorders (CDs), such as autism. It is to be expected that this …
(ID) and related cognitive disorders (CDs), such as autism. It is to be expected that this …
Nurturing brain plasticity: impact of environmental enrichment
L Baroncelli, C Braschi, M Spolidoro… - Cell Death & …, 2010 - nature.com
Environmental enrichment (EE) is known to profoundly affect the central nervous system
(CNS) at the functional, anatomical and molecular level, both during the critical period and …
(CNS) at the functional, anatomical and molecular level, both during the critical period and …
DYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for Drug Development in Down Syndrome
A Duchon, Y Herault - Frontiers in behavioral neuroscience, 2016 - frontiersin.org
Down syndrome (DS) is one of the leading causes of intellectual disability, and patients with
DS face various health issues, including learning and memory deficits, congenital heart …
DS face various health issues, including learning and memory deficits, congenital heart …
Rho GTPases, dendritic structure, and mental retardation
SE Newey, V Velamoor, EE Govek… - Journal of …, 2005 - Wiley Online Library
A consistent feature of neurons in patients with mental retardation is abnormal dendritic
structure and/or alterations in dendritic spine morphology. Deficits in the regulation of the …
structure and/or alterations in dendritic spine morphology. Deficits in the regulation of the …
Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome
L Chakrabarti, TK Best, NP Cramer, RSE Carney… - Nature …, 2010 - nature.com
Over-inhibition is thought to be one of the underlying causes of the cognitive deficits in
Ts65Dn mice, the most widely used model of Down syndrome. We found a direct link …
Ts65Dn mice, the most widely used model of Down syndrome. We found a direct link …