Molecular and cellular mechanisms of liver fibrosis and its regression
T Kisseleva, D Brenner - Nature Reviews Gastroenterology & …, 2021 - nature.com
Chronic liver injury leads to liver inflammation and fibrosis, through which activated
myofibroblasts in the liver secrete extracellular matrix proteins that generate the fibrous scar …
myofibroblasts in the liver secrete extracellular matrix proteins that generate the fibrous scar …
[HTML][HTML] Crosstalk between oxidative stress and inflammatory liver injury in the pathogenesis of alcoholic liver disease
Alcoholic liver disease (ALD) is characterized by the injury, inflammation, and scarring in the
liver owing to excessive alcohol consumption. Currently, ALD is a leading cause for liver …
liver owing to excessive alcohol consumption. Currently, ALD is a leading cause for liver …
Recent advances in alcohol-related liver disease (ALD): summary of a Gut round table meeting
Alcohol-related liver disease (ALD), which includes a range of disorders of different severity
and is one of the most prevalent types of liver disease worldwide, has recently regained …
and is one of the most prevalent types of liver disease worldwide, has recently regained …
[HTML][HTML] Pathogenesis of alcoholic liver disease: role of oxidative metabolism
E Ceni, T Mello, A Galli - World Journal of Gastroenterology: WJG, 2014 - ncbi.nlm.nih.gov
Alcohol consumption is a predominant etiological factor in the pathogenesis of chronic liver
diseases, resulting in fatty liver, alcoholic hepatitis, fibrosis/cirrhosis, and hepatocellular …
diseases, resulting in fatty liver, alcoholic hepatitis, fibrosis/cirrhosis, and hepatocellular …
Alcoholic liver disease
HK Seitz, R Bataller, H Cortez-Pinto, B Gao… - Nature reviews Disease …, 2018 - nature.com
Alcoholic liver disease (ALD) is the most prevalent type of chronic liver disease worldwide.
ALD can progress from alcoholic fatty liver (AFL) to alcoholic steatohepatitis (ASH), which is …
ALD can progress from alcoholic fatty liver (AFL) to alcoholic steatohepatitis (ASH), which is …
[HTML][HTML] Fibrosis related inflammatory mediators: role of the IL-10 cytokine family
Importance of chronic fibroproliferative diseases (FDs) including pulmonary fibrosis, chronic
kidney diseases, inflammatory bowel disease, and cardiovascular or liver fibrosis is rapidly …
kidney diseases, inflammatory bowel disease, and cardiovascular or liver fibrosis is rapidly …
An open‐label, dose‐escalation study to assess the safety and efficacy of IL‐22 agonist F‐652 in patients with alcohol‐associated hepatitis
Background and Aims Interleukin‐22 has beneficial effects on inflammation and impaired
hepatic regeneration that characterize alcohol‐associated hepatitis (AH). F‐652 is a …
hepatic regeneration that characterize alcohol‐associated hepatitis (AH). F‐652 is a …
Therapeutic potential of targeting regulatory mechanisms of hepatic stellate cell activation in liver fibrosis
K Baghaei, S Mazhari, S Tokhanbigli… - Drug discovery today, 2022 - Elsevier
Highlights•Hepatic stellate cell activation/myofibroblast transition is the main driver of liver
fibrosis.•Paracrine signals from adjacent cells induce stellate cell activation.•Alteration in …
fibrosis.•Paracrine signals from adjacent cells induce stellate cell activation.•Alteration in …
[HTML][HTML] Role of neutrophils in the pathogenesis of nonalcoholic steatohepatitis
Nonalcoholic fatty liver disease (NAFLD) includes a spectrum of liver disorders, from fatty
liver to nonalcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma …
liver to nonalcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma …
Linking pathogenic mechanisms of alcoholic liver disease with clinical phenotypes
Alcoholic liver disease (ALD) develops in approximately 20% of alcoholic patients, with a
higher prevalence in females. ALD progression is marked by fatty liver and hepatocyte …
higher prevalence in females. ALD progression is marked by fatty liver and hepatocyte …