Single-atom logic for heterocycle editing
Medicinal chemistry continues to be impacted by new synthetic methods. Particularly sought
after, especially at the drug discovery stage, is the ability to enact the desired chemical …
after, especially at the drug discovery stage, is the ability to enact the desired chemical …
Kinetics, spectroscopy, and computational chemistry of arylnitrenes
NP Gritsan, MS Platz - Chemical reviews, 2006 - ACS Publications
Arylnitrenes are very reactive and short-lived intermediates commonly generated by
decomposition of aryl azides. Although other arylnitrene precursors are known1 and their …
decomposition of aryl azides. Although other arylnitrene precursors are known1 and their …
Tandem C/N-difunctionalization of nitroarenes: reductive amination and annulation by a ring expansion/contraction sequence
A synthetic method for the reductive transformation of nitroarenes into ortho-aminated and-
annulated products is reported. The method operates via the exhaustive deoxygenation of …
annulated products is reported. The method operates via the exhaustive deoxygenation of …
A Photochemical Strategy for ortho‐Aminophenol Synthesis via Dearomative‐Rearomative Coupling Between Aryl Azides and Alcohols
Abstract ortho‐Aminophenols are aromatic derivatives featuring vicinal N‐and O‐based
functionalities commonly found in the structures of many high‐value materials. These …
functionalities commonly found in the structures of many high‐value materials. These …
[图书][B] CRC Handbook of Organic Photochemistry and Photobiology, Volumes 1 & 2
WM Horspool, F Lenci - 2003 - taylorfrancis.com
The second edition of this best-selling handbook is bigger, more comprehensive, and now
completely current. In addition to thorough updates to the discussions featured in the first …
completely current. In addition to thorough updates to the discussions featured in the first …
An Improved PIII/PV═O-Catalyzed Reductive C–N Coupling of Nitroaromatics and Boronic Acids by Mechanistic Differentiation of Rate- and Product-Determining …
Experimental, spectroscopic, and computational studies are reported that provide an
evidence-based mechanistic description of an intermolecular reductive C–N coupling of …
evidence-based mechanistic description of an intermolecular reductive C–N coupling of …
Recent progress on reductive coupling of nitroarenes by using organosilanes as convenient reductants
Y Gao, S Yang, Y Huo, XQ Hu - Advanced Synthesis & …, 2020 - Wiley Online Library
Nitroarenes are stable, low‐cost, and readily available starting materials. The directly utilize
nitroarenes in synthetically valuable C− N bond formation is of great significance, because …
nitroarenes in synthetically valuable C− N bond formation is of great significance, because …
Photochemical reactions in the synthesis of protein–drug conjugates
The ability to modify biologically active molecules such as antibodies with drug molecules,
fluorophores or radionuclides is crucial in drug discovery and target identification. Classic …
fluorophores or radionuclides is crucial in drug discovery and target identification. Classic …
Study of the Chemistry of ortho- and para-Biphenylnitrenes by Laser Flash Photolysis and Time-Resolved IR Experiments and by B3LYP and CASPT2 Calculations
ML Tsao, N Gritsan, TR James, MS Platz… - Journal of the …, 2003 - ACS Publications
The photochemistry of ortho-biphenyl azide (1a) has been studied by laser flash photolysis
(LFP), with UV− vis and IR detection of the transient intermediates formed. LFP (266 nm) of …
(LFP), with UV− vis and IR detection of the transient intermediates formed. LFP (266 nm) of …
Charting the Chemical and Mechanistic Scope of Light-Triggered Protein Ligation
The creation of discrete, covalent bonds between a protein and a functional molecule like a
drug, fluorophore, or radiolabeled complex is essential for making state-of-the-art tools that …
drug, fluorophore, or radiolabeled complex is essential for making state-of-the-art tools that …