Recent advances in the field of immunometabolism support the concept that fundamental
processes in T cell biology, such as TCR-mediated activation and T helper lineage …

Natural killer (NK) cells survey host tissues for signs of infection, transformation or stress
and, true to their name, kill target cells that have become useless or are detrimental to the …

To fulfill the bioenergetic and biosynthetic demand of proliferation, T cells reprogram their
metabolic pathways from fatty acid β-oxidation and pyruvate oxidation via the TCA cycle to …

The immunological process of clonal selection requires a rapid burst in lymphocyte
proliferation, and this involves a metabolic shift to provide energy and the building blocks of …

Haematopoietic stem cells (HSCs) and their subsequent progenitors produce blood cells,
but the precise nature and kinetics of this production is a contentious issue. In one model …

Upon infection, antigen-specific CD8+ T lymphocyte responses display a highly
reproducible pattern of expansion and contraction that is thought to reflect a uniform …

Abstract High-throughput 3′ single-cell RNA-sequencing (scRNA-seq) allows cost-
effective, detailed characterization of individual immune cells from tissues. Current …

Maintenance of immunological memory has been proposed to rely on stem-cell-like
lymphocytes. However, data supporting this hypothesis are focused on the developmental …

Highlights•Effector T cells require increased glucose uptake/processing via aerobic
glycolysis.•Glutaminolysis is essential for activated effector T cell metabolism.•Activated …

Autoimmune thyroid disease (AITD) is one of the most common organ‐specific autoimmune
disorders. It mainly manifests as Hashimoto's thyroiditis (HT) and Graves' disease (GD). HT …