Metabolic pathways integrate to support tissue homeostasis and to prompt changes in cell
phenotype. In particular, the heart consumes relatively large amounts of substrate not only to …

Gene therapy has revolutionized the field of medicine, offering new hope for those with
common and rare diseases. For nearly three decades, adeno-associated virus (AAV) has …

Heart failure represents the end point of a variety of cardiovascular diseases. It is a growing
health burden and a leading cause of death worldwide. To date, limited treatment options …

Lipid metabolism rewiring in gastric adenocarcinoma (GA) pathogenesis is still not clearly
elucidated. This study aimed to describe the role of lipid catabolism in GA patient outcomes …

Exercise-induced heart growth provides protection against cardiovascular disease, whereas
disease-induced heart growth leads to heart failure. These distinct forms of growth are …

Despite advances in treatment over the past decade, heart failure remains a significant
public health burden and a leading cause of death in the developed world. Gene therapy …

Heart failure (HF) is a debilitating and deadly chronic disease, with almost 50% of patients
with HF dying within 5 years of diagnosis. With limited effective therapies to treat or cure HF …

Diabetic cardiomyopathy describes heart disease in patients with diabetes who have no
other cardiac conditions but have a higher risk of developing heart failure. Specific therapies …

Reversible lysine acetylation regulates the activity of cardiac metabolic enzymes, including
those controlling fuel substrate metabolism. Mitochondrial-targeted GCN5L1 and SIRT3 …

Open-access gene expression data sets provide a useful resource for identifying novel drug
targets and biomarkers. The IGF1–PI3K pathway is a critical mediator of physiological …