This review considers efflux of substances from brain parenchyma quantified as values of
clearances (CL, stated in µL g− 1 min− 1). Total clearance of a substance is the sum of …

Glycogen metabolism has important implications for the functioning of the brain, especially
the cooperation between astrocytes and neurons. According to various research data, in a …

Glucose is the obligate energetic fuel for the mammalian brain, and most studies of cerebral
energy metabolism assume that the majority of cerebral glucose utilization fuels neuronal …

To determine whether plasma lactate can be a significant fuel for human brain energy
metabolism, infusions of [3-13C] lactate and 1H-13C polarization transfer spectroscopy were …

Hypoglycemic coma and brain injury are potential complications of insulin therapy. Certain
neurons in the hippocampus and cerebral cortex are uniquely vulnerable to hypoglycemic …

Prior 13C magnetic resonance spectroscopy (MRS) experiments, which simultaneously
measured in vivo rates of total glutamate-glutamine cycling (Vcyc (tot)) and neuronal …

Quantitative assessment of cerebral glucose consumption rate (CMRglc) and tricarboxylic
acid cycle flux (VTCA) is crucial for understanding neuroenergetics under …

There are fewer than normal glucose transporters at the blood-brain barrier (BBB) in
Alzheimer's disease (AD). When reduced expression of transporters aggravates the …

After administration of enriched [1-13C] glucose, the rate of 13C label incorporation into
glutamate C4, C3, and C2, glutamine C4, C3, and C2, and aspartate C2 and C3 was …

The brain contains a small but significant amount of glycogen, which has long been
considered to play an insignificant role in the brain. In this study, brain glycogen metabolism …