The development of our society has been based on the use of biodiversity, especially for
medicines and nutrition. Brazil is the nation with the largest biodiversity in the world …

The use of natural products has definitely been the most successful strategy in the discovery
of novel medicines. Secondary metabolites from terrestrial and marine organisms have …

We describe herein the design and development of an innovative tool called the NuBBE
database (NuBBEDB), a new Web-based database, which incorporates several classes of …

Histone lysine specific demethylase 1 (LSD1) was reported to be overexpressed in several
human cancers and recognized as a promising anticancer drug target. In the current study …

Natural products are the inspiration for many valuable therapeutic agents and attest to
biodiversity being a rich source of new molecular structures. Their value as templates for …

Ethnopharmacological relevance Parasitic infections impose a significant burden on public
health worldwide. European pharmacopoeia records and ethnopharmacological studies …

Plant parasitic nematodes are destructive endoparasites having deleterious effect on about
5000 agricultural crops notably vegetables, fruits, field crops, ornamental plants, and even …

Azadirachta indica (A. indica) has traditionally been used to treat parasitic diseases, while its
antiparasitic compounds and their mechanism remain ambiguous. Acetylcholinesterase …

Some novel valerolactam derivatives of 5 (6)-substituted-(1H-benzimidazol-2-yl-amine)
were constructed based on the union of two structural domains with anthelmintic activity. The …

Previously we designed a series of pyridinic anticholinesterasic compounds based on
molecular hybridization between tacrine and the natural piperidine alkaloid (−)-3-O …