Major advances have occurred in recent years in our understanding of HIV-1 assembly,
release and maturation, as work in this field has been propelled forwards by developments …

Tetraspanins are a family of proteins with four transmembrane domains that play a role in
many aspects of cell biology and physiology; they are also used by several pathogens for …

Toxoplasma gondii is a master manipulator capable of effectively siphoning the resources
from the host cell for its intracellular subsistence. However, the molecular underpinnings of …

Particles that bud off from the cell surface, including viruses and microvesicles, typically
have a unique membrane protein composition distinct from that of the originating plasma …

Tetraspanins (Tspans) are a family of four-span transmembrane proteins, known as plasma
membrane “master organizers.” They form Tspan-enriched microdomains (TEMs or TERMs) …

The fundamental mechanisms of protein and lipid organization at the plasma membrane
have continued to engage researchers for decades. Among proposed models, one idea has …

Although the human immunodeficiency virus type 1 lipid envelope has been reported to be
enriched with host cell sphingomyelin and cholesterol, the molecular mechanism of the …

Virus assembly and interaction with host-cell proteins occur at length scales below the
diffraction limit of visible light. Novel super-resolution microscopy techniques achieve …

HIV/AIDS is a chronic and debilitating disease that cannot be cured with current antiretroviral
drugs. While combinatorial antiretroviral therapy (cART) can potently suppress HIV-1 …

Membrane binding of the HIV-1 group-specific antigen (Gag) structural protein, a critical step
in viral assembly at the plasma membrane, is mediated by the myristoylated, highly basic …