The nuclear lamina is an important structural determinant for the nuclear envelope as a
whole, attaching chromatin domains to the nuclear periphery and localizing some nuclear …

The nucleus is the largest organelle and is commonly depicted in the center of the cell. Yet
during cell division, migration, and differentiation, it frequently moves to an asymmetric …

Lipid composition determines organelle identity; however, whether the lipid composition of
the inner nuclear membrane (INM) domain of the ER contributes to its identity is not known …

In cardiovascular tissues, changes in the mechanical properties of the extracellular matrix
are associated with cellular de-differentiation and with subsequent functional declines …

Quantitative mass spectrometry has established proteome-wide regulation of protein
abundance and post-translational modifications in various biological processes. Here, we …

Whether gene repositioning to the nuclear periphery during differentiation adds another
layer of regulation to gene expression remains controversial. Here, we resolve this by …

Despite decades of research, cancer metastasis remains an incompletely understood
process that is as complex as it is devastating. In recent years, there has been an increasing …

One hypothesis to explain how mutations in the same nuclear envelope proteins yield
pathologies focused in distinct tissues is that as yet unidentified tissue-specific partners …

Emerin, a conserved LEM-domain protein, is among the few nuclear membrane proteins for
which extensive basic knowledge—biochemistry, partners, functions, localizations …

Mutations in nuclear envelope proteins (NEPs) cause devastating genetic diseases, known
as envelopathies, that primarily affect the heart and skeletal muscle. A mutation in the NEP …