Exosomal PD-L1 in cancer and other fields: recent advances and perspectives

MM Lu, Y Yang - Frontiers in Immunology, 2024 - frontiersin.org
PD-1/PD-L1 signaling is a key factor of local immunosuppression in the tumor
microenvironment. Immune checkpoint inhibitors targeting PD-1/PD-L1 signaling have …

Novel Insights into the Regulation of Exosomal PD-L1 in Cancer: From Generation to Clinical Application

J Liu, J Qin, L Liang, X Zhang, J Gao, Y Hao… - European Journal of …, 2024 - Elsevier
Programmed cell death ligand 1 (PD-L1) interacts with programmed cell death 1 (PD-1),
leading to T cell exhaustion and promoting tumor cell survival, ultimately mediating …

Dual-Recognition-Mediated Autocatalytic Amplification Assay for the Subpopulations of PD-L1 Positive Extracellular Vesicle

Y Ren, K Ge, QQ Tang, X Liang, L Fan, K Ye… - Analytical …, 2024 - ACS Publications
The PD-L1 protein on extracellular vesicles (EVs) is a promising biomarker for tumor
immunotherapy. However, PD-L1+ EVs have various cell origins, so further analysis of the …

Selective enrichment and detection of PD-L1 positive extracellular vesicles derived from human plasma and patient derived tumor cells

Y Ren, K Ge, W Lu, W Peng, H Che, J Ma, C Jia… - Sensors and Actuators B …, 2023 - Elsevier
Recent studies reported that the level of PD-L1 carried by extracellular vesicles (EVs) could
distinguish the presence of tumors and had a good correlation with the response to …

Molecular Docking and Intracellular Translocation of Extracellular Vesicles for Efficient Drug Delivery

Y Matsuzaka, R Yashiro - International Journal of Molecular Sciences, 2022 - mdpi.com
Extracellular vesicles (EVs), including exosomes, mediate intercellular communication by
delivering their contents, such as nucleic acids, proteins, and lipids, to distant target cells …