Astrocytes: a central element in neurological diseases

M Pekny, M Pekna, A Messing, C Steinhäuser… - Acta …, 2016 - Springer
The neurone-centred view of the past disregarded or downplayed the role of astroglia as a
primary component in the pathogenesis of neurological diseases. As this concept is …

Glial fibrillary acidic protein (GFAP) and the astrocyte intermediate filament system in diseases of the central nervous system

EM Hol, M Pekny - Current opinion in cell biology, 2015 - Elsevier
Glial fibrillary acidic protein (GFAP) is the hallmark intermediate filament (IF; also known as
nanofilament) protein in astrocytes, a main type of glial cells in the central nervous system …

Astrocyte reactivity and reactive astrogliosis: costs and benefits

M Pekny, M Pekna - Physiological reviews, 2014 - journals.physiology.org
Astrocytes are the most abundant cells in the central nervous system (CNS) that provide
nutrients, recycle neurotransmitters, as well as fulfill a wide range of other homeostasis …

The dual role of astrocyte activation and reactive gliosis

M Pekny, U Wilhelmsson, M Pekna - Neuroscience letters, 2014 - Elsevier
Astrocyte activation and reactive gliosis accompany most of the pathologies in the brain,
spinal cord, and retina. Reactive gliosis has been described as constitutive, graded, multi …

[HTML][HTML] Reactive gliosis in the pathogenesis of CNS diseases

M Pekny, M Pekna - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2016 - Elsevier
Astrocytes maintain the homeostasis of the central nervous system (CNS) by eg recycling of
neurotransmitters and providing nutrients to neurons. Astrocytes function also as key …

Astrocyte activation and reactive gliosis—a new target in stroke?

M Pekny, U Wilhelmsson, T Tatlisumak, M Pekna - Neuroscience letters, 2019 - Elsevier
Stroke is an acute insult to the central nervous system (CNS) that triggers a sequence of
responses in the acute, subacute as well as later stages, with prominent involvement of …

Plasticity in the neonatal brain following hypoxic‐ischaemic injury

E Rocha-Ferreira, M Hristova - Neural plasticity, 2016 - Wiley Online Library
Hypoxic‐ischaemic damage to the developing brain is a leading cause of child death, with
high mortality and morbidity, including cerebral palsy, epilepsy, and cognitive disabilities …

Lycium Barbarum Polysaccharides Reduce Neuronal Damage, Blood-Retinal Barrier Disruption and Oxidative Stress in Retinal Ischemia/Reperfusion Injury

SY Li, D Yang, CM Yeung, WY Yu, RCC Chang, KF So… - PloS one, 2011 - journals.plos.org
Neuronal cell death, glial cell activation, retinal swelling and oxidative injury are
complications in retinal ischemia/reperfusion (I/R) injuries. Lycium barbarum …

Effect of neuroinflammation on synaptic organization and function in the developing brain: implications for neurodevelopmental and neurodegenerative disorders

A Mottahedin, M Ardalan, T Chumak, I Riebe… - Frontiers in cellular …, 2017 - frontiersin.org
The brain is a plastic organ where both the intrinsic CNS milieu and extrinsic cues play
important roles in shaping and wiring neural connections. The perinatal period constitutes a …

[HTML][HTML] Effects of prenatal photobiomodulation treatment on neonatal hypoxic ischemia in rat offspring

L Yang, Y Dong, C Wu, H Youngblood, Y Li, X Zong… - Theranostics, 2021 - ncbi.nlm.nih.gov
Neonatal hypoxic-ischemic (HI) injury is a severe complication often leading to neonatal
death and long-term neurobehavioral deficits in children. Currently, the only treatment option …