Chemokines and cytokines are critical for initiating and coordinating the organized and
sequential recruitment and activation of cells into Mycobacterium tuberculosis-infected …

Tuberculosis is a disease of the lung, and efficient transmission is dependent on the
generation of a lesion in the lung, which results in a bacterium-laden cough. Mycobacterium …

Heightened morbidity and mortality in pulmonary tuberculosis (TB) are consequences of
complex disease processes triggered by the causative agent, Mycobacterium tuberculosis …

Induction of immunosuppressive T-regulatory cells (Tregs) is a desirable goal in
autoimmunity, and perhaps other immune diseases of activation. One promising avenue is …

Tumor necrosis factor (TNF) is one of the main cytokines regulating a pro-inflammatory
environment. It has been related to several cell functions, for instance, phagocytosis …

Cytokine receptors are critical regulators of the antimycobacterial immune response, playing
a key role in initiating and coordinating the recruitment and activation of immune cells during …

Host directed immunomodulation represents potential new adjuvant therapies in infectious
diseases such as tuberculosis. Major cytokines like TNFα exert a multifold role in host …

Macrophages are essential cells of the innate immune response against microbial
infections, and they have the ability to adapt under both pro-and anti-inflammatory …

Macrophages are key type of antigen-presenting cells that arbitrate the first line of defense
against various intracellular pathogens. Tuberculosis, both pulmonary and extrapulmonary …

Objective To study the involvement of Treg cells expressing tumor necrosis factor receptor
type II (TNFRII) in exerting control of inflammation in experimental models and in the …