Hallmarks of intestinal stem cells

A Baulies, N Angelis, VSW Li - Development, 2020 - journals.biologists.com
Intestinal stem cells (ISCs) are highly proliferative cells that fuel the continuous renewal of
the intestinal epithelium. Understanding their regulatory mechanisms during tissue …

Intestinal cellular heterogeneity and disease development revealed by single-cell technology

Y Wang, W Song, S Yu, Y Liu, YG Chen - Cell Regeneration, 2022 - Springer
The intestinal epithelium is responsible for food digestion and nutrient absorption and plays
a critical role in hormone secretion, microorganism defense, and immune response. These …

Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains

RK Zwick, P Kasparek, B Palikuqi, S Viragova… - Nature Cell …, 2024 - nature.com
A key aspect of nutrient absorption is the exquisite division of labour across the length of the
small intestine, with individual nutrients taken up at different proximal: distal positions. For …

Intestinal epithelial c-Maf expression determines enterocyte differentiation and nutrient uptake in mice

C Cosovanu, P Resch, S Jordan, A Lehmann… - Journal of Experimental …, 2022 - rupress.org
The primary function of the small intestine (SI) is to absorb nutrients to maintain whole-body
energy homeostasis. Enterocytes are the major epithelial cell type facilitating nutrient …

[HTML][HTML] Capybara: A computational tool to measure cell identity and fate transitions

W Kong, YC Fu, EM Holloway, G Garipler, X Yang… - Cell Stem Cell, 2022 - cell.com
Measuring cell identity in development, disease, and reprogramming is challenging as cell
types and states are in continual transition. Here, we present Capybara, a computational tool …

Xenotransplanted human organoids identify transepithelial zinc transport as a key mediator of intestinal adaptation

MES Sampah, H Moore, R Ahmad, J Duess… - Nature …, 2024 - nature.com
Short bowel syndrome (SBS) leads to severe morbidity and mortality. Intestinal adaptation is
crucial in improving outcomes. To understand the human gene pathways associated with …

Nutritional Balance Matters: Assessing the Ramifications of Vitamin A Deficiency on Poultry Health and Productivity

Y Shastak, W Pelletier - Poultry, 2023 - mdpi.com
Vitamin A, a critical micronutrient, plays a vital role in maintaining poultry health and
maximizing productivity. This comprehensive review paper conducts a thorough analysis of …

An overview of short-bowel syndrome in pediatric patients: focus on clinical management and prevention of complications

C Caporilli, G Giannì, F Grassi, S Esposito - Nutrients, 2023 - mdpi.com
Short-bowel syndrome (SBS) in pediatric age is defined as a malabsorptive state, resulting
from congenital malformations, significant small intestine surgical resection or disease …

Teduglutide promotes epithelial tight junction pore function in murine short bowel syndrome to alleviate intestinal insufficiency

J Reiner, P Berlin, J Wobar, H Schäffler… - Digestive diseases and …, 2020 - Springer
Background In short bowel syndrome, epithelial surface loss results in impaired nutrient
absorption and may lead to intestinal insufficiency or intestinal failure. Nucleotide …

Short bowel syndrome

BA Shakhsheer, BW Warner - Current treatment options in pediatrics, 2019 - Springer
Purpose of review Short gut syndrome is life-altering and life-threatening disease resulting
most often from massive small bowel resection. Recent advances in understanding of the …