Neurons are highly polarized cells with extensive axonal and dendritic projections that send
and receive signals over long distances. Neuronal polarity requires sorting and maintaining …

Summary Hyperpolarizing GABA AR currents, the unitary events that underlie synaptic
inhibition, are dependent upon efficient Cl− extrusion, a process that is facilitated by the …

ABSTRACT GABA is the primary inhibitory neurotransmitter in the adult brain and through its
actions on GABAARs, it protects against excitotoxicity and seizure activity, ensures temporal …

Objective Animal studies remain essential for understanding mechanisms of epilepsy and
identifying new therapeutic targets. However, existing animal models of epilepsy do not …

Protein-protein interactions (PPIs) are of fundamental importance for our understanding of
physiology and pathology. PPIs involving short, linear motifs play a major role in …

Fast synaptic inhibition is dependent on targeting specific GABAAR subtypes to dendritic
and axon initial segment (AIS) synapses. Synaptic GABAARs are typically assembled from …

Objective SCN8A encephalopathy is a developmental epileptic encephalopathy typically
caused by de novo gain‐of‐function mutations in Nav1. 6. Severely affected individuals …

The axon initial segment (AIS) is the site of action potential (AP) initiation in most neurons
and is thus a critical site in the regulation of neuronal excitability. Normal function within the …

Presympathetic neurons in the paraventricular nucleus of the hypothalamus (PVN) play a
key role in cardiovascular regulation. We have previously shown that brain-derived …

Background Excitation/inhibition imbalance (E/I imbalance), which involves an increase of
alpha-amino-3-hydroxy-5-methyl-4-isoxazole (AMPA) receptors (AMPARs) and decrease of …