[HTML][HTML] The function of the axon initial segment in neuronal polarity
Neurons are highly polarized cells with extensive axonal and dendritic projections that send
and receive signals over long distances. Neuronal polarity requires sorting and maintaining …
and receive signals over long distances. Neuronal polarity requires sorting and maintaining …
[HTML][HTML] Direct activation of KCC2 arrests benzodiazepine refractory status epilepticus and limits the subsequent neuronal injury in mice
R Jarvis, SFJ Ng, AJ Nathanson, RA Cardarelli… - Cell Reports …, 2023 - cell.com
Summary Hyperpolarizing GABA AR currents, the unitary events that underlie synaptic
inhibition, are dependent upon efficient Cl− extrusion, a process that is facilitated by the …
inhibition, are dependent upon efficient Cl− extrusion, a process that is facilitated by the …
GABA System as the Cause and Effect in Early Development
I Topchiy, J Mohbat, OO Folorunso… - Neuroscience & …, 2024 - Elsevier
ABSTRACT GABA is the primary inhibitory neurotransmitter in the adult brain and through its
actions on GABAARs, it protects against excitotoxicity and seizure activity, ensures temporal …
actions on GABAARs, it protects against excitotoxicity and seizure activity, ensures temporal …
Collaborative Cross mice reveal extreme epilepsy phenotypes and genetic loci for seizure susceptibility
Objective Animal studies remain essential for understanding mechanisms of epilepsy and
identifying new therapeutic targets. However, existing animal models of epilepsy do not …
identifying new therapeutic targets. However, existing animal models of epilepsy do not …
High-throughput determination of protein affinities using unmodified peptide libraries in nanomolar scale
C Schulte, V Khayenko, NF Nordblom, F Tippel, V Peck… - Iscience, 2021 - cell.com
Protein-protein interactions (PPIs) are of fundamental importance for our understanding of
physiology and pathology. PPIs involving short, linear motifs play a major role in …
physiology and pathology. PPIs involving short, linear motifs play a major role in …
Spectrin-beta 2 facilitates the selective accumulation of GABAA receptors at somatodendritic synapses
JL Smalley, N Cho, SFJ Ng, C Choi… - Communications …, 2023 - nature.com
Fast synaptic inhibition is dependent on targeting specific GABAAR subtypes to dendritic
and axon initial segment (AIS) synapses. Synaptic GABAARs are typically assembled from …
and axon initial segment (AIS) synapses. Synaptic GABAARs are typically assembled from …
Gabra2 is a genetic modifier of Scn8a encephalopathy in the mouse
Objective SCN8A encephalopathy is a developmental epileptic encephalopathy typically
caused by de novo gain‐of‐function mutations in Nav1. 6. Severely affected individuals …
caused by de novo gain‐of‐function mutations in Nav1. 6. Severely affected individuals …
Inhibitory synapse formation at the axon initial segment
The axon initial segment (AIS) is the site of action potential (AP) initiation in most neurons
and is thus a critical site in the regulation of neuronal excitability. Normal function within the …
and is thus a critical site in the regulation of neuronal excitability. Normal function within the …
BDNF shifts excitatory-inhibitory balance in the paraventricular nucleus of the hypothalamus to elevate blood pressure
D Thorsdottir, Z Einwag… - Journal of …, 2021 - journals.physiology.org
Presympathetic neurons in the paraventricular nucleus of the hypothalamus (PVN) play a
key role in cardiovascular regulation. We have previously shown that brain-derived …
key role in cardiovascular regulation. We have previously shown that brain-derived …
[HTML][HTML] The recycling of AMPA receptors/GABAa receptors is related to neuronal excitation/inhibition imbalance and may be regulated by KIF5A
S Li, H Huang, X Wei, L Ye, M Ma… - Annals of Translational …, 2022 - ncbi.nlm.nih.gov
Background Excitation/inhibition imbalance (E/I imbalance), which involves an increase of
alpha-amino-3-hydroxy-5-methyl-4-isoxazole (AMPA) receptors (AMPARs) and decrease of …
alpha-amino-3-hydroxy-5-methyl-4-isoxazole (AMPA) receptors (AMPARs) and decrease of …