Serotonin reuptake inhibitor antidepressants, including selective serotonin reuptake
inhibitors (SSRIs; ie, citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and …

Importance Precise estimation of the drug metabolism capacity for individual patients is
crucial for adequate dose personalization. Objective To quantify the difference in the …

Selective serotonin reuptake inhibitors (SSRIs) are primary treatment options for major
depressive and anxiety disorders. CYP2D6 and CYP2C19 polymorphisms can influence the …

Introduction: Generalized anxiety disorder (GAD) often begins during adolescence or early
adulthood and persists throughout the lifespan. Randomized controlled trials support the …

Abstract The Dutch Pharmacogenetics Working Group (DPWG) guideline presented here,
presents the gene-drug interaction between the genes CYP2C19 and CYP2D6 and …

Interindividual differences in drug disposition are important causes for adverse drug
reactions and lack of drug response. The majority of phase I and phase II drug-metabolizing …

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• CYP2C19 polymorphisms may have
clinical consequences in relation to drugs extensively metabolized by the enzyme.• Recently …

The cytochrome P450, family 2, subfamily C, polypeptide 19 (CYP2C19) gene is located
within a cluster of cytochrome P450 genes (centromere-CYP2C18-CYP2C19-CYP2C9 …

Polymorphic drug-metabolizing enzymes (DMEs) are responsible for the metabolism of the
majority of psychotropic drugs. By explaining a large portion of variability in individual drug …

Background Cannabidiol (CBD), a major nonintoxicating constituent of cannabis, exhibits
anxiolytic properties in preclinical and human studies and is of interest as a novel …