Living organisms are continuously exposed to a myriad of DNA damaging agents that can
impact health and modulate disease‐states. However, robust DNA repair and damage …

The expansion of repeated sequences is the cause of over 30 inherited genetic diseases,
including Huntington disease, myotonic dystrophy (types 1 and 2), fragile X syndrome, many …

RNA-DNA hybrids are a major internal cause of DNA damage within cells, and their
degradation by RNase H enzymes is important for maintaining genomic stability. Here, we …

While recent studies have identified higher than anticipated heterogeneity of mutation rate
across genomic regions, mutations in exons and introns are assumed to be generated at the …

The methylation of histone H3 at lysine 36 (H3K36me) is essential for maintaining genomic
stability. Indeed, this methylation mark is essential for proper transcription, recombination …

Reactive oxygen and nitrogen species (eg H 2 O 2, nitric oxide) confer redox regulation of
essential cellular signaling pathways such as cell differentiation, proliferation, migration and …

Eukaryotic genomes are packaged into chromatin, which is the physiological substrate for all
DNA transactions, including DNA damage and repair. Chromatin organization imposes …

The faithful DNA replication is a critical event for cell survival and inheritance. However,
exogenous or endogenous sources of damage challenge the accurate synthesis of DNA …

The recovery of stalled replication forks depends on the controlled resection of nascent DNA
and on the loading of cohesin. These processes operate in the context of nascent chromatin …

In eukaryotic cells, the nucleus houses the genomic material of the cell. The physical
properties of the nucleus and its ability to sense external mechanical cues are tightly linked …