The role of protein loops and linkers in conformational dynamics and allostery
Proteins are dynamic entities that undergo a plethora of conformational changes that may
take place on a wide range of time scales. These changes can be as small as the rotation of …
take place on a wide range of time scales. These changes can be as small as the rotation of …
Psychrophilic enzymes: from folding to function and biotechnology
G Feller - Scientifica, 2013 - Wiley Online Library
Psychrophiles thriving permanently at near‐zero temperatures synthesize cold‐active
enzymes to sustain their cell cycle. Genome sequences, proteomic, and transcriptomic …
enzymes to sustain their cell cycle. Genome sequences, proteomic, and transcriptomic …
Function and biotechnology of extremophilic enzymes in low water activity
R Karan, MD Capes, S DasSarma - Aquatic biosystems, 2012 - Springer
Enzymes from extremophilic microorganisms usually catalyze chemical reactions in non-
standard conditions. Such conditions promote aggregation, precipitation, and denaturation …
standard conditions. Such conditions promote aggregation, precipitation, and denaturation …
Rebuilding the lid region from conformational and dynamic features to engineering applications of lipase in foods: Current status and future prospects
The applications of lipases in esterification, amidation, and transesterification have
broadened their potential in the production of fine compounds with high cumulative values …
broadened their potential in the production of fine compounds with high cumulative values …
Computation of enzyme cold adaptation
Earth has several environments that are potentially hostile to life. The survival of organisms
has required the expression of proteins that are adapted to function under extreme …
has required the expression of proteins that are adapted to function under extreme …
An optimal distance cutoff for contact-based Protein Structure Networks using side-chain centers of mass
J Salamanca Viloria, MF Allega, M Lambrughi… - Scientific reports, 2017 - nature.com
Proteins are highly dynamic entities attaining a myriad of different conformations. Protein
side chains change their states during dynamics, causing clashes that are propagated at …
side chains change their states during dynamics, causing clashes that are propagated at …
Biotechnology of cold-active proteases
S Joshi, T Satyanarayana - Biology, 2013 - mdpi.com
The bulk of Earth's biosphere is cold (< 5° C) and inhabited by psychrophiles. Biocatalysts
from psychrophilic organisms (psychrozymes) have attracted attention because of their …
from psychrophilic organisms (psychrozymes) have attracted attention because of their …
Computer simulations explain the anomalous temperature optimum in a cold-adapted enzyme
J Sočan, M Purg, J Åqvist - Nature communications, 2020 - nature.com
Cold-adapted enzymes from psychrophilic species show the general characteristics of being
more heat labile, and having a different balance between enthalpic and entropic …
more heat labile, and having a different balance between enthalpic and entropic …
Comparing mutagenesis and simulations as tools for identifying functionally important sequence changes for protein thermal adaptation
Comparative studies of orthologous proteins of species evolved at different temperatures
have revealed consistent patterns of temperature-related variation in thermal stabilities of …
have revealed consistent patterns of temperature-related variation in thermal stabilities of …
Increasing activity and thermal resistance of Bacillus gibsonii alkaline protease (BgAP) by directed evolution
R Martinez, F Jakob, R Tu, P Siegert… - Biotechnology and …, 2013 - Wiley Online Library
Abstract Bacillus gibsonii Alkaline Protease (BgAP) is a recently reported subtilisin protease
exhibiting activity and stability properties suitable for applications in laundry and dish …
exhibiting activity and stability properties suitable for applications in laundry and dish …