To provide a T-cell population that will respond promptly to foreign antigen, the immune
system looks inward, using the variety of self-antigens to select and maintain a diverse …

CD8 T cells respond to viral infections but also participate in defense against bacterial and
protozoal infections. In the last few years, as new methods to accurately quantify and …

Viral infections induce extensive T cell proliferation in vivo, but the specificity of the majority
of the responding T cells has not been defined. To address this issue we used tetramers of …

Abstract During LCMV infection, CD8+ T cells expand greatly. Bystander activation has been
thought to play a role because few cells score as LCMV specific in limiting dilution analysis …

The thymus undergoes age-related atrophy, coincident with increased circulating sex
steroids from puberty. The impact of thymic atrophy is most profound in clinical conditions …

Major histocompatibility complex (mhc)–encoded molecules govern immune responses by
presenting antigenic peptides to T cells. The extensive polymorphism of genes encoding …

Maturation of dendritic cells (DC), leading to migration and increased T cell stimulatory
capacity, is essential for the initiation of immune responses. This process is triggered by a …

T lymphocytes play a central role in the generation of a protective immune response in many
microbial infections. After immunization, dendritic cells take up microbial antigens and traffic …

Localized cutaneous herpes simplex virus type 1 (HSV-1) infection leads to arming and
initial expansion of cytotoxic T lymphocytes (CTLs) in the draining popliteal lymph nodes …

Viral infections often induce potent CD8 T cell responses that play a key role in antiviral
immunity. After viral clearance, the vast majority of the expanded CD8 T cells undergo …