Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?

P Rada, Á González-Rodríguez, C García-Monzón… - Cell death & …, 2020 - nature.com
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease
worldwide. NAFLD stages range from simple steatosis (NAFL) to non-alcoholic …

How does hepatic lipid accumulation lead to lipotoxicity in non-alcoholic fatty liver disease?

Y Geng, KN Faber, VE de Meijer, H Blokzijl… - Hepatology …, 2021 - Springer
Background Non-alcoholic fatty liver disease (NAFLD), characterized as excess lipid
accumulation in the liver which is not due to alcohol use, has emerged as one of the major …

[HTML][HTML] Pathogenesis and treatment of non-alcoholic steatohepatitis and its fibrosis

KC Lee, PS Wu, HC Lin - Clinical and molecular hepatology, 2023 - ncbi.nlm.nih.gov
The initial presentation of non-alcoholic steatohepatitis (NASH) is hepatic steatosis. The
dysfunction of lipid metabolism within hepatocytes caused by genetic factors, diet, and …

Squalene epoxidase drives NAFLD-induced hepatocellular carcinoma and is a pharmaceutical target

D Liu, CC Wong, L Fu, H Chen, L Zhao, C Li… - Science translational …, 2018 - science.org
Nonalcoholic fatty liver disease (NAFLD)–induced hepatocellular carcinoma (HCC) is an
emerging malignancy in the developed world; however, mechanisms that contribute to its …

METTL3-m6A-Rubicon axis inhibits autophagy in nonalcoholic fatty liver disease

Z Peng, Y Gong, X Wang, W He, L Wu, L Zhang… - Molecular Therapy, 2022 - cell.com
N6-methyladenosine (m 6 A) mRNA modification plays critical roles in various biological
events and is involved in multiple complex diseases. However, the role of m 6 A modification …

Autophagy and its role in gastric cancer

Y Cao, Y Luo, J Zou, J Ouyang, Z Cai, X Zeng, H Ling… - Clinica Chimica …, 2019 - Elsevier
Autophagy, which is tightly regulated by a series of autophagy-related genes (ATGs), is a
vital intracellular homeostatic process through which defective proteins and organelles are …

Autophagy inhibition enhances PD-L1 expression in gastric cancer

X Wang, WKK Wu, J Gao, Z Li, B Dong, X Lin… - Journal of Experimental …, 2019 - Springer
Background Autophagy, a process for degrading intracellular substances to maintain basal
metabolic turnover, is known to be perturbed in gastric cancer. Programmed cell death-1 …

Emerging mechanisms of immunocoagulation in sepsis and septic shock

D Tang, H Wang, TR Billiar, G Kroemer, R Kang - Trends in immunology, 2021 - cell.com
Sepsis and septic shock driven by microbial infections are still among the most challenging
health problems, causing 11 million deaths worldwide every year. How does the host's …

Dysfunction of autophagy in high-fat diet-induced non-alcoholic fatty liver disease

Q Ren, Q Sun, J Fu - Autophagy, 2024 - Taylor & Francis
Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases
with a global rising prevalence, which is closely associated with a high-fat diet (HFD) intake …

Moderate treadmill exercise alleviates NAFLD by regulating the biogenesis and autophagy of lipid droplet

Y Yang, X Li, Z Liu, X Ruan, H Wang, Q Zhang, L Cao… - Nutrients, 2022 - mdpi.com
Lipid droplet is a dynamic organelle that undergoes periods of biogenesis and degradation
under environmental stimuli. The excessive accumulation of lipid droplets is the major …