Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?
P Rada, Á González-Rodríguez, C García-Monzón… - Cell death & …, 2020 - nature.com
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease
worldwide. NAFLD stages range from simple steatosis (NAFL) to non-alcoholic …
worldwide. NAFLD stages range from simple steatosis (NAFL) to non-alcoholic …
How does hepatic lipid accumulation lead to lipotoxicity in non-alcoholic fatty liver disease?
Y Geng, KN Faber, VE de Meijer, H Blokzijl… - Hepatology …, 2021 - Springer
Background Non-alcoholic fatty liver disease (NAFLD), characterized as excess lipid
accumulation in the liver which is not due to alcohol use, has emerged as one of the major …
accumulation in the liver which is not due to alcohol use, has emerged as one of the major …
[HTML][HTML] Pathogenesis and treatment of non-alcoholic steatohepatitis and its fibrosis
KC Lee, PS Wu, HC Lin - Clinical and molecular hepatology, 2023 - ncbi.nlm.nih.gov
The initial presentation of non-alcoholic steatohepatitis (NASH) is hepatic steatosis. The
dysfunction of lipid metabolism within hepatocytes caused by genetic factors, diet, and …
dysfunction of lipid metabolism within hepatocytes caused by genetic factors, diet, and …
Squalene epoxidase drives NAFLD-induced hepatocellular carcinoma and is a pharmaceutical target
Nonalcoholic fatty liver disease (NAFLD)–induced hepatocellular carcinoma (HCC) is an
emerging malignancy in the developed world; however, mechanisms that contribute to its …
emerging malignancy in the developed world; however, mechanisms that contribute to its …
METTL3-m6A-Rubicon axis inhibits autophagy in nonalcoholic fatty liver disease
Z Peng, Y Gong, X Wang, W He, L Wu, L Zhang… - Molecular Therapy, 2022 - cell.com
N6-methyladenosine (m 6 A) mRNA modification plays critical roles in various biological
events and is involved in multiple complex diseases. However, the role of m 6 A modification …
events and is involved in multiple complex diseases. However, the role of m 6 A modification …
Autophagy and its role in gastric cancer
Y Cao, Y Luo, J Zou, J Ouyang, Z Cai, X Zeng, H Ling… - Clinica Chimica …, 2019 - Elsevier
Autophagy, which is tightly regulated by a series of autophagy-related genes (ATGs), is a
vital intracellular homeostatic process through which defective proteins and organelles are …
vital intracellular homeostatic process through which defective proteins and organelles are …
Autophagy inhibition enhances PD-L1 expression in gastric cancer
Background Autophagy, a process for degrading intracellular substances to maintain basal
metabolic turnover, is known to be perturbed in gastric cancer. Programmed cell death-1 …
metabolic turnover, is known to be perturbed in gastric cancer. Programmed cell death-1 …
Emerging mechanisms of immunocoagulation in sepsis and septic shock
Sepsis and septic shock driven by microbial infections are still among the most challenging
health problems, causing 11 million deaths worldwide every year. How does the host's …
health problems, causing 11 million deaths worldwide every year. How does the host's …
Dysfunction of autophagy in high-fat diet-induced non-alcoholic fatty liver disease
Q Ren, Q Sun, J Fu - Autophagy, 2024 - Taylor & Francis
Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases
with a global rising prevalence, which is closely associated with a high-fat diet (HFD) intake …
with a global rising prevalence, which is closely associated with a high-fat diet (HFD) intake …
Moderate treadmill exercise alleviates NAFLD by regulating the biogenesis and autophagy of lipid droplet
Y Yang, X Li, Z Liu, X Ruan, H Wang, Q Zhang, L Cao… - Nutrients, 2022 - mdpi.com
Lipid droplet is a dynamic organelle that undergoes periods of biogenesis and degradation
under environmental stimuli. The excessive accumulation of lipid droplets is the major …
under environmental stimuli. The excessive accumulation of lipid droplets is the major …