High-voltage electrical pulses in oncology: irreversible electroporation, electrochemotherapy, gene electrotransfer, electrofusion, and electroimmunotherapy

B Geboers, HJ Scheffer, PM Graybill, AH Ruarus… - Radiology, 2020 - pubs.rsna.org
This review summarizes the use of high-voltage electrical pulses (HVEPs) in clinical
oncology to treat solid tumors with irreversible electroporation (IRE) and …

Cardiac ablation with pulsed electric fields: principles and biophysics

A Sugrue, E Maor, F Del-Carpio Munoz, AM Killu… - Europace, 2022 - academic.oup.com
Pulsed electric fields (PEFs) have emerged as an ideal cardiac ablation modality. At present
numerous clinical trials in humans are exploring PEF as an ablation strategy for both atrial …

A theoretical argument for extended interpulse delays in therapeutic high-frequency irreversible electroporation treatments

KN Aycock, Y Zhao, MF Lorenzo… - IEEE Transactions on …, 2021 - ieeexplore.ieee.org
High-frequency irreversible electroporation (H-FIRE) is a tissue ablation modality employing
bursts of electrical pulses in a positive phase–interphase delay (d 1)–negative phase …

Experimental high-frequency irreversible electroporation using a single-needle delivery approach for nonthermal pancreatic ablation in vivo

TJ O'Brien, M Passeri, MF Lorenzo, JK Sulzer… - Journal of Vascular and …, 2019 - Elsevier
Purpose To investigate the feasibility of single-needle high-frequency irreversible
electroporation (SN-HFIRE) to create reproducible tissue ablations in an in vivo pancreatic …

Mathematical modeling of the thermal effects of irreversible electroporation for in vitro, in vivo, and clinical use: a systematic review

P Agnass, E van Veldhuisen… - International journal …, 2020 - Taylor & Francis
Introduction Irreversible electroporation (IRE) is a relatively new ablation method for the
treatment of unresectable cancers. Although the main mechanism of IRE is electric …

[HTML][HTML] Irreversible electroporation for locally advanced pancreatic cancer

FEF Timmer, B Geboers, AH Ruarus… - Techniques in vascular …, 2020 - Elsevier
Several minimally invasive image guided tumor ablation techniques have been added to the
treatment spectrum for locally advanced pancreatic cancer (LAPC). Irreversible …

Median 4‐year outcomes of salvage irreversible electroporation for localized radio‐recurrent prostate cancer

B Geboers, MJ Scheltema, A Blazevski… - BJU …, 2023 - Wiley Online Library
Objectives To evaluate the safety, and short to mid‐term oncological and quality‐of‐life
(QoL) outcomes of focal irreversible electroporation (IRE) for radio‐recurrent prostate cancer …

System and method for ablating a tissue site by electroporation with real-time pulse monitoring

IIR Neal - US Patent 12,114,911, 2024 - Google Patents
A medical system for ablating a tissue site by electroporation with real-time pulse monitoring
during an electroporation treatment procedure is provided. The treatment control module …

Temperature dependence of high frequency irreversible electroporation evaluated in a 3D tumor model

CC Fesmire, RA Petrella, CA Fogle, DA Gerber… - Annals of Biomedical …, 2020 - Springer
Electroporation is a bioelectric phenomenon used to deliver target molecules into cells in
vitro and irreversible electroporation (IRE) is an emerging cancer therapy used to treat …

Device and methods for delivery of high frequency electrical pulses for non-thermal ablation

B Christopher, RV Davalos, MB Sano - US Patent 11,382,681, 2022 - Google Patents
The present invention relates to the field of biomedical engineering and medical treatment of
diseases and disorders. Methods, devices, and systems for in vivo treatment of cell …