Clinical insights into small cell lung cancer: Tumor heterogeneity, diagnosis, therapy, and future directions

Z Megyesfalvi, CM Gay, H Popper… - CA: a cancer journal …, 2023 - Wiley Online Library
Small cell lung cancer (SCLC) is characterized by rapid growth and high metastatic capacity.
It has strong epidemiologic and biologic links to tobacco carcinogens. Although the majority …

Small-cell lung cancer

CM Rudin, E Brambilla, C Faivre-Finn… - Nature Reviews Disease …, 2021 - nature.com
Small-cell lung cancer (SCLC) represents about 15% of all lung cancers and is marked by
an exceptionally high proliferative rate, strong predilection for early metastasis and poor …

[HTML][HTML] Small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up☆

AMC Dingemans, M Früh, A Ardizzoni… - Annals of …, 2021 - annalsofoncology.org
Small-cell lung cancer (SCLC) is the most aggressive form of lung cancer. Although SCLC is
characterised by rapid responses to chemotherapy (ChT) and sensitivity to radiotherapy …

Evolution of systemic therapy for stages I–III non-metastatic non-small-cell lung cancer

JE Chaft, A Rimner, W Weder, CG Azzoli… - Nature reviews Clinical …, 2021 - nature.com
The treatment goal for patients with early-stage lung cancer is cure. Multidisciplinary
discussions of surgical resectability and medical operability determine the modality of …

Efficacy and safety of rovalpituzumab tesirine in third-line and beyond patients with DLL3-expressing, relapsed/refractory small-cell lung cancer: results from the phase …

D Morgensztern, B Besse, L Greillier… - Clinical Cancer …, 2019 - AACR
Purpose: Although extensive-stage small-cell lung cancer (SCLC) is highly responsive to
first-line therapy, virtually all patients develop resistance with short survival. Rovalpituzumab …

Unravelling the biology of SCLC: implications for therapy

JK Sabari, BH Lok, JH Laird, JT Poirier… - Nature reviews Clinical …, 2017 - nature.com
Small-cell lung cancer (SCLC) is an aggressive malignancy associated with a poor
prognosis. First-line treatment has remained unchanged for decades, and a paucity of …

Lung cancer—major changes in the American Joint Committee on Cancer eighth edition cancer staging manual

R Rami‐Porta, H Asamura, WD Travis… - CA: a cancer journal …, 2017 - Wiley Online Library
Answer questions and earn CME/CNE The revision for the eighth edition of the tumor, node,
and metastasis (TNM) classification of lung cancer was based on analyses of the …

YAP drives fate conversion and chemoresistance of small cell lung cancer

Q Wu, J Guo, Y Liu, Q Zheng, X Li, C Wu, D Fang… - Science …, 2021 - science.org
Small cell lung cancer (SCLC) has a high degree of plasticity and is characterized by a
remarkable response to chemotherapy followed by the development of resistance. Here, we …

Small cell lung cancer, version 2.2022, NCCN clinical practice guidelines in oncology

AKP Ganti, BW Loo, M Bassetti, C Blakely… - Journal of the National …, 2021 - jnccn.org
The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Small Cell Lung
Cancer (SCLC) provide recommended management for patients with SCLC, including …

[HTML][HTML] Scientific advances in lung cancer 2015

AS Tsao, GV Scagliotti, PA Bunn Jr, DP Carbone… - Journal of Thoracic …, 2016 - Elsevier
Lung cancer continues to be a major global health problem; the disease is diagnosed in
more than 1.6 million new patients each year. However, significant progress is underway in …