[HTML][HTML] Paramecium Genetics, Genomics, and Evolution
The ciliate genus Paramecium served as one of the first model systems in microbial
eukaryotic genetics, contributing much to the early understanding of phenomena as diverse …
eukaryotic genetics, contributing much to the early understanding of phenomena as diverse …
Paramecium epigenetics in development and proliferation
The term epigenetics is used for any layer of genetic information aside from the DNA base‐
sequence information. Mammalian epigenetic research increased our understanding of …
sequence information. Mammalian epigenetic research increased our understanding of …
MITE infestation accommodated by genome editing in the germline genome of the ciliate Blepharisma
BKB Seah, M Singh, C Emmerich… - Proceedings of the …, 2023 - National Acad Sciences
During their development following sexual conjugation, ciliates excise numerous internal
eliminated sequences (IESs) from a copy of the germline genome to produce the functional …
eliminated sequences (IESs) from a copy of the germline genome to produce the functional …
The compact macronuclear genome of the ciliate Halteria grandinella: a transcriptome-like genome with 23,000 nanochromosomes
How to achieve protein diversity by genome and transcriptome processing is essential for
organismal complexity and adaptation. The present work identifies that the macronuclear …
organismal complexity and adaptation. The present work identifies that the macronuclear …
Programmed DNA elimination: silencing genes and repetitive sequences in somatic cells
MV Zagoskin, J Wang - Biochemical Society Transactions, 2021 - portlandpress.com
In a multicellular organism, the genomes of all cells are in general the same. Programmed
DNA elimination is a notable exception to this genome constancy rule. DNA elimination …
DNA elimination is a notable exception to this genome constancy rule. DNA elimination …
GC content, but not nucleosome positioning, directly contributes to intron splicing efficiency in Paramecium
S Gnan, M Matelot, M Weiman, O Arnaiz… - Genome …, 2022 - genome.cshlp.org
Eukaryotic genes are interrupted by introns that must be accurately spliced from mRNA
precursors. With an average length of 25 nt, the more than 90,000 introns of Paramecium …
precursors. With an average length of 25 nt, the more than 90,000 introns of Paramecium …
[HTML][HTML] Somatic genome architecture and molecular evolution are decoupled in “young” linage-specific gene families in ciliates
XX Maurer-Alcalá, A Cote-L'Heureux… - Plos one, 2024 - journals.plos.org
The evolution of lineage-specific gene families remains poorly studied across the eukaryotic
tree of life, with most analyses focusing on the recent evolution of de novo genes in model …
tree of life, with most analyses focusing on the recent evolution of de novo genes in model …
Phenotypic plasticity through disposable genetic adaptation in ciliates
Ciliates have an extraordinary genetic system in which each cell harbors two distinct kinds of
nucleus, a transcriptionally active somatic nucleus and a quiescent germline nucleus. The …
nucleus, a transcriptionally active somatic nucleus and a quiescent germline nucleus. The …
One Cell, Two Gears: Extensive Somatic Genome Plasticity Accompanies High Germline Genome Stability in Paramecium
Mutation accumulation (MA) experiments are conventionally employed to study
spontaneous germline mutations. However, MA experiments can also shed light on somatic …
spontaneous germline mutations. However, MA experiments can also shed light on somatic …
Transcribed germline-limited coding sequences in Oxytricha trifallax
The germline-soma divide is a fundamental distinction in developmental biology, and
different genes are expressed in germline and somatic cells throughout metazoan life …
different genes are expressed in germline and somatic cells throughout metazoan life …